PIPA586221
Caspase 8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586221-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA586221 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Caspase 8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
64044, 841
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.
Q14790, Q9JHX4
Gene Symbols
Casp8
Immunogen
Synthetic peptide, corresponding to amino acids 312-368 of Human Caspase-8.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Compare Similar Items
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Antigen: Caspase 8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 64044, 841
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: Q14790, Q9JHX4
Gene Symbols: Casp8
Immunogen: Synthetic peptide, corresponding to amino acids 312-368 of Human Caspase-8.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
64044, 841
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
Q14790, Q9JHX4
Gene Symbols:
Casp8
Immunogen:
Synthetic peptide, corresponding to amino acids 312-368 of Human Caspase-8.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CHK2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Chek2
Gene Alias: CDS1, cds1 homolog, Checkpoint kinase 2, Checkpoint like protein CHK2, checkpoint-like protein CHK2, Chek2, Chk2, Chk2 (phospho T68), Chk2 (pThr68), CHK2 checkpoint homolog, CHK2 checkpoint homolog (S. pombe), Chk2 phospho, Chk2 phospho T68, del9, EC 2.7.11.1, hCds1, HuCds 1, HuCds1, kinase Chk2, LFS2, OTTHUMP00000199044, OTTHUMP00000199045, OTTHUMP00000199064, OTTHUMP00000199115, OTTHUMP00000199116, phospho Chk2 (T68), phospho Thr68 Chk2, PP1425, protein kinase Chk2, Rad53, Rad53 homolog, RP11-436C9.1, Serine/threonine protein kinase Chk2, serine/threonine-protein kinase Chk2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11200, 114212, 50883
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: O96017, Q9Z265
Gene Symbols: Chek2
Immunogen: Synthetic peptide, corresponding to amino acids 351-400 of Human Chk2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CHK2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Chek2
Gene Alias:
CDS1, cds1 homolog, Checkpoint kinase 2, Checkpoint like protein CHK2, checkpoint-like protein CHK2, Chek2, Chk2, Chk2 (phospho T68), Chk2 (pThr68), CHK2 checkpoint homolog, CHK2 checkpoint homolog (S. pombe), Chk2 phospho, Chk2 phospho T68, del9, EC 2.7.11.1, hCds1, HuCds 1, HuCds1, kinase Chk2, LFS2, OTTHUMP00000199044, OTTHUMP00000199045, OTTHUMP00000199064, OTTHUMP00000199115, OTTHUMP00000199116, phospho Chk2 (T68), phospho Thr68 Chk2, PP1425, protein kinase Chk2, Rad53, Rad53 homolog, RP11-436C9.1, Serine/threonine protein kinase Chk2, serine/threonine-protein kinase Chk2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11200, 114212, 50883
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
O96017, Q9Z265
Gene Symbols:
Chek2
Immunogen:
Synthetic peptide, corresponding to amino acids 351-400 of Human Chk2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cyclin B1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Ccnb1
Gene Alias: Ccn-2, CCNB, Ccnb1, Ccnb1-rs1, Ccnb1-rs13, Cycb, Cycb1, Cycb1-rs1, Cycb-4, Cycb-5, cyclin B, cyclin B1, cyclin B1, related sequence 1, cyclin B1, related sequence 13, G2/mitotic-specific cyclin B1, G2/mitotic-specific cyclin-B1, I79_013589, OTTHUMP00000221981, OTTHUMP00000223023
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25203, 268697, 891
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P14635, P24860, P30277
Gene Symbols: Ccnb1
Immunogen: Synthetic peptide, corresponding to amino acids 90-140 of Human Cyclin B1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cyclin B1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Ccnb1
Gene Alias:
Ccn-2, CCNB, Ccnb1, Ccnb1-rs1, Ccnb1-rs13, Cycb, Cycb1, Cycb1-rs1, Cycb-4, Cycb-5, cyclin B, cyclin B1, cyclin B1, related sequence 1, cyclin B1, related sequence 13, G2/mitotic-specific cyclin B1, G2/mitotic-specific cyclin-B1, I79_013589, OTTHUMP00000221981, OTTHUMP00000223023
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25203, 268697, 891
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P14635, P24860, P30277
Gene Symbols:
Ccnb1
Immunogen:
Synthetic peptide, corresponding to amino acids 90-140 of Human Cyclin B1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cyclin D3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CCND3
Gene Alias: 9230106B05Rik, AA682053, AL024085, AW146355, C78795, CCND 3, Ccnd3, CGD3, cyclin D3, CyclinD3, Cyl-3, D3 type cyclin, D3-type cyclin, G1/S-specific cyclin-D3, OTTHUMP00000223415, RP5-973N23.3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12445, 25193, 896
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P30281, P30282, P48961
Gene Symbols: CCND3
Immunogen: Synthetic peptide, corresponding to amino acids 249-299 of Human Cyclin D3.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cyclin D3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CCND3
Gene Alias:
9230106B05Rik, AA682053, AL024085, AW146355, C78795, CCND 3, Ccnd3, CGD3, cyclin D3, CyclinD3, Cyl-3, D3 type cyclin, D3-type cyclin, G1/S-specific cyclin-D3, OTTHUMP00000223415, RP5-973N23.3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12445, 25193, 896
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P30281, P30282, P48961
Gene Symbols:
CCND3
Immunogen:
Synthetic peptide, corresponding to amino acids 249-299 of Human Cyclin D3.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG