PIPA586935
Caspase 8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586935-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA586935 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Caspase 8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12370, 64044, 841
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
O89110, Q14790, Q9JHX4
Gene Symbols
Casp8
Immunogen
Synthetic peptide, corresponding to amino acids 350-400 of Human Caspase8.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
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Antigen: Caspase 8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12370, 64044, 841
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: O89110, Q14790, Q9JHX4
Gene Symbols: Casp8
Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human Caspase8.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12370, 64044, 841
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
O89110, Q14790, Q9JHX4
Gene Symbols:
Casp8
Immunogen:
Synthetic peptide, corresponding to amino acids 350-400 of Human Caspase8.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: OTUB1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: OTUB1
Gene Alias: AI850305, Deubiquitinating enzyme OTUB1, deubiquitinating enzyme OTUB1 {ECO:0000250, EMBL:AAI66771.1}, FLJ20113, FLJ40710, hOTU1, HSPC263, hypothetical protein LOC540984, MGC111158, MGC4584, OTB1, OTU deubiquitinase, ubiquitin aldehyde binding 1, OTU domain, ubiquitin aldehyde binding 1, OTU domain-containing ubiquitin aldehyde-binding protein 1, OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250, OTU1, OTUB1, otub1 {ECO:0000312, otubain 1, otubain-1, otubain-1 {ECO:0000250, OTU-domain Ubal-binding 1, Ubiquitin thioesterase OTUB1, ubiquitin thioesterase OTUB1 {ECO:0000250, ubiquitin-specific protease otubain 1, ubiquitin-specific-processing protease OTUB1, ubiquitin-specific-processing protease OTUB1 {ECO:0000250, UniProtKB:Q7TQI3}
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 107260, 293705, 55611
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: B2RYG6, Q7TQI3, Q96FW1
Gene Symbols: OTUB1
Immunogen: Synthetic peptide, corresponding Human OTUB1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
OTUB1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
OTUB1
Gene Alias:
AI850305, Deubiquitinating enzyme OTUB1, deubiquitinating enzyme OTUB1 {ECO:0000250, EMBL:AAI66771.1}, FLJ20113, FLJ40710, hOTU1, HSPC263, hypothetical protein LOC540984, MGC111158, MGC4584, OTB1, OTU deubiquitinase, ubiquitin aldehyde binding 1, OTU domain, ubiquitin aldehyde binding 1, OTU domain-containing ubiquitin aldehyde-binding protein 1, OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250, OTU1, OTUB1, otub1 {ECO:0000312, otubain 1, otubain-1, otubain-1 {ECO:0000250, OTU-domain Ubal-binding 1, Ubiquitin thioesterase OTUB1, ubiquitin thioesterase OTUB1 {ECO:0000250, ubiquitin-specific protease otubain 1, ubiquitin-specific-processing protease OTUB1, ubiquitin-specific-processing protease OTUB1 {ECO:0000250, UniProtKB:Q7TQI3}
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
107260, 293705, 55611
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
B2RYG6, Q7TQI3, Q96FW1
Gene Symbols:
OTUB1
Immunogen:
Synthetic peptide, corresponding Human OTUB1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Collagen IV
Classification: Polyclonal
Conjugate: Unconjugated
Gene: COL4A5
Gene Alias: [a]3(IV), [a]4(IV), alpha 1 type IV collagen, alpha type IV collagen basement membrane, alpha1(IV) collagen, alpha-2 collagen type IV, alpha-3 type IV collagen, alpha3(IV), Arresten, Bru, BSVD, CA44, Canstatin, Col4a1, Col4a-1, COL4A1 NC1 domain, Col4a2, Col4a-2, COL4A3, col4a4, Collagen 4, Collagen alpha-1(IV) chain, collagen alpha-2(IV) chain, Collagen alpha-3(IV) chain, collagen alpha-4(IV) chain, collagen IV, alpha-1 polypeptide, collagen IV, alpha-3 polypeptide, Collagen IV, alpha-4 polypeptide, collagen of basement membrane, alpha-1 chain, collagen of basement membrane, alpha-4 chain, collagen type IV alpha 1 chain, collagen type IV alpha 2, collagen type IV alpha 2 chain, collagen type IV alpha 3 chain, collagen type IV alpha 4 chain, collagen type IV alpha3 chain, collagen, type IV, alpha 1, collagen, type IV, alpha 2, collagen, type IV, alpha 3, collagen, type IV, alpha 3 (Goodpasture antigen), collagen, type IV, alpha 4, Del(8)44H, Del(8)Bru44H, E130010M05Rik, Goodpasture antigen, ICH, LOW QUALITY PROTEIN: collagen alpha-1(IV) chain, LOW QUALITY PROTEIN: collagen alpha-3(IV) chain, LOW QUALITY PROTEIN: collagen alpha-4(IV) chain, POREN2, procollagen alpha1(IV), procollagen, type IV, alpha 1, procollagen, type IV, alpha 2, procollagen, type IV, alpha 3, procollagen, type IV, alpha 4, RATOR, Raw, retinal anterior wiring, Svc, tumstatin, Type IV Collagen
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1282, 1284, 1285, 1286, 1287
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P02462, P08572, P29400, P53420, Q01955
Gene Symbols: COL4A1, COL4A2, Col4a3, COL4A4, COL4A5
Immunogen: Synthetic peptide, corresponding to Human COL4A1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Collagen IV
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
COL4A5
Gene Alias:
[a]3(IV), [a]4(IV), alpha 1 type IV collagen, alpha type IV collagen basement membrane, alpha1(IV) collagen, alpha-2 collagen type IV, alpha-3 type IV collagen, alpha3(IV), Arresten, Bru, BSVD, CA44, Canstatin, Col4a1, Col4a-1, COL4A1 NC1 domain, Col4a2, Col4a-2, COL4A3, col4a4, Collagen 4, Collagen alpha-1(IV) chain, collagen alpha-2(IV) chain, Collagen alpha-3(IV) chain, collagen alpha-4(IV) chain, collagen IV, alpha-1 polypeptide, collagen IV, alpha-3 polypeptide, Collagen IV, alpha-4 polypeptide, collagen of basement membrane, alpha-1 chain, collagen of basement membrane, alpha-4 chain, collagen type IV alpha 1 chain, collagen type IV alpha 2, collagen type IV alpha 2 chain, collagen type IV alpha 3 chain, collagen type IV alpha 4 chain, collagen type IV alpha3 chain, collagen, type IV, alpha 1, collagen, type IV, alpha 2, collagen, type IV, alpha 3, collagen, type IV, alpha 3 (Goodpasture antigen), collagen, type IV, alpha 4, Del(8)44H, Del(8)Bru44H, E130010M05Rik, Goodpasture antigen, ICH, LOW QUALITY PROTEIN: collagen alpha-1(IV) chain, LOW QUALITY PROTEIN: collagen alpha-3(IV) chain, LOW QUALITY PROTEIN: collagen alpha-4(IV) chain, POREN2, procollagen alpha1(IV), procollagen, type IV, alpha 1, procollagen, type IV, alpha 2, procollagen, type IV, alpha 3, procollagen, type IV, alpha 4, RATOR, Raw, retinal anterior wiring, Svc, tumstatin, Type IV Collagen
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1282, 1284, 1285, 1286, 1287
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P02462, P08572, P29400, P53420, Q01955
Gene Symbols:
COL4A1, COL4A2, Col4a3, COL4A4, COL4A5
Immunogen:
Synthetic peptide, corresponding to Human COL4A1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-ATM (Ser1981)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ATM
Gene Alias: AI256621, AT mutated, A-T mutated, A-T mutated homolog, AT mutated protein, AT1, ATA, Ataxia t, Ataxia telangiectasia gene mutated in human beings, ataxia telangiectasia mutated, Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, Atm, ATM (phospho S1981), ATM (pS1981), ATM (pSer1981), ATM phospho S1981, ATM phospho Ser1981, ATM serine/threonine kinase, C030026E19Rik, DKFZp781A0353, EC 2.7.1.37, MGC74674, phospho ATM, phospho S1981 ATM, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11920, 300711, 472
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: Q13315, Q62388
Gene Symbols: ATM
Immunogen: A synthetic peptide corresponding to residues in Human ATM around the phosphorylation site of ser1981.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-ATM (Ser1981)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ATM
Gene Alias:
AI256621, AT mutated, A-T mutated, A-T mutated homolog, AT mutated protein, AT1, ATA, Ataxia t, Ataxia telangiectasia gene mutated in human beings, ataxia telangiectasia mutated, Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, Atm, ATM (phospho S1981), ATM (pS1981), ATM (pSer1981), ATM phospho S1981, ATM phospho Ser1981, ATM serine/threonine kinase, C030026E19Rik, DKFZp781A0353, EC 2.7.1.37, MGC74674, phospho ATM, phospho S1981 ATM, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11920, 300711, 472
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
Q13315, Q62388
Gene Symbols:
ATM
Immunogen:
A synthetic peptide corresponding to residues in Human ATM around the phosphorylation site of ser1981.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG