PIPA587373
Caspase 8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA587373-Each-of-1 | In Stock | ₹ 44,277.30 |
PIPA587373 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,277.30
GST (18%): ₹ 7,969.914
Total Price: ₹ 52,247.214
Antigen
Caspase 8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12370, 64044, 841
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.99 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
O89110, Q14790, Q9JHX4
Gene Symbols
Casp8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 376-479 of human Caspase 8 (NP_2035191)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Raji, HL-60; Cellular Location: Cytoplasm Immunogen sequence: EEQPYLEMDL SSPQTRYIPD EADFLLGMAT VNNCVSYRNP AEGTWYIQSL CQSLRERCPR GDDILTILTE VNYEVSNKDD KKNMGKQMPQ PTFTLRKKLV FPSD Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Compare Similar Items
Show Difference
Antigen: Caspase 8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12370, 64044, 841
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.99 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: O89110, Q14790, Q9JHX4
Gene Symbols: Casp8
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 376-479 of human Caspase 8 (NP_2035191)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12370, 64044, 841
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.99 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
O89110, Q14790, Q9JHX4
Gene Symbols:
Casp8
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 376-479 of human Caspase 8 (NP_2035191)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Caspase 12
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CASP12
Gene Alias: CASP12, CASP-12, CASP12P1, caspase 12, caspase 12 (gene/pseudogene), caspase 12 pseudogene 1, caspase-12, Inactive caspase-12, OTTMUSP00000045799, OTTMUSP00000045802, OTTMUSP00000045803, UNQ9415, UNQ9415/PRO34398
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 100506742, 12364, 156117
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.368 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: O08736, Q6UXS9, Q920D5
Gene Symbols: CASP12
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-12 (NP_0011779452)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 12
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CASP12
Gene Alias:
CASP12, CASP-12, CASP12P1, caspase 12, caspase 12 (gene/pseudogene), caspase 12 pseudogene 1, caspase-12, Inactive caspase-12, OTTMUSP00000045799, OTTMUSP00000045802, OTTMUSP00000045803, UNQ9415, UNQ9415/PRO34398
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
100506742, 12364, 156117
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.368 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
O08736, Q6UXS9, Q920D5
Gene Symbols:
CASP12
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-12 (NP_0011779452)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: c-Raf
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Raf1
Gene Alias: 6430402F14Rik, AA990557, BB129353, CMD1NN, CRAF, C-RAF, C-Raf proto-oncogene, serine/threonine kinase, Craf1, Craf1 transforming, D830050J10Rik, EC 2.7.11.1, kinase Raf1, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV), murine sarcoma 3611 oncogene 1, NS5, Oncogene RAF1, OTTHUMP00000207813, OTTHUMP00000209389, proto-oncogene c-RAF, RAF, raf proto-oncogene serine/threonine protein kinase, RAF proto-oncogene serine/threonine-protein kinase, RAF1, Raf-1, Raf-1 proto-oncogene, serine/threonine kinase, sarcoma 3611 oncogene, v-Raf, v-raf-1 leukemia viral oncogene 1, vraf1 murine le, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1, v-raf-leukemia viral oncogene 1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 110157, 5894
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.99 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P04049, Q99N57
Gene Symbols: Raf1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human Raf1 (NP_0028711)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
c-Raf
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Raf1
Gene Alias:
6430402F14Rik, AA990557, BB129353, CMD1NN, CRAF, C-RAF, C-Raf proto-oncogene, serine/threonine kinase, Craf1, Craf1 transforming, D830050J10Rik, EC 2.7.11.1, kinase Raf1, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV), murine sarcoma 3611 oncogene 1, NS5, Oncogene RAF1, OTTHUMP00000207813, OTTHUMP00000209389, proto-oncogene c-RAF, RAF, raf proto-oncogene serine/threonine protein kinase, RAF proto-oncogene serine/threonine-protein kinase, RAF1, Raf-1, Raf-1 proto-oncogene, serine/threonine kinase, sarcoma 3611 oncogene, v-Raf, v-raf-1 leukemia viral oncogene 1, vraf1 murine le, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1, v-raf-leukemia viral oncogene 1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
110157, 5894
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.99 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P04049, Q99N57
Gene Symbols:
Raf1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human Raf1 (NP_0028711)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: DOK4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DOK4
Gene Alias: docking protein 4, Dok4, Downstream of tyrosine kinase 4, insulin receptor substrate 5, IRS5, IRS-5
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 114255, 361364, 55715
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.09 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: Q8TEW6, Q99KE3
Gene Symbols: DOK4
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human DOK4 (NP_0605802)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
DOK4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DOK4
Gene Alias:
docking protein 4, Dok4, Downstream of tyrosine kinase 4, insulin receptor substrate 5, IRS5, IRS-5
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
114255, 361364, 55715
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.09 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
Q8TEW6, Q99KE3
Gene Symbols:
DOK4
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human DOK4 (NP_0605802)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG