PIPA586422
ICAD Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586422-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA586422 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
ICAD
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DFFA
Gene Alias
A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114214, 13347, 1676
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.
O00273, O54786
Gene Symbols
DFFA
Immunogen
Synthetic peptide, corresponding to amino acids 151-200 of Human ICAD.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
- ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
- Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
- ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
- In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
- The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
- In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
- There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.
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Antigen: ICAD
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 114214, 13347, 1676
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: O00273, O54786
Gene Symbols: DFFA
Immunogen: Synthetic peptide, corresponding to amino acids 151-200 of Human ICAD.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ICAD
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
114214, 13347, 1676
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
O00273, O54786
Gene Symbols:
DFFA
Immunogen:
Synthetic peptide, corresponding to amino acids 151-200 of Human ICAD.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: RAD50
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RAD50
Gene Alias: 153 kDa protein, DNA repair protein RAD50, hRad50, hsRAD50, I79_004319, mRad50, Mrell, MRX complex DNA-binding subunit, N0872, NBSLD, Rad50, RAD50 2, RAD50 double strand break repair protein, RAD50 homolog (S. cerevisiae), RAD50 homolog, double strand break repair protein, RAD50 PEN, RAD502, RAD50-2, RAD50-3, Rad50l, YNL250W
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10111, 19360, 64012
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P70388, Q92878, Q9JIL8
Gene Symbols: RAD50
Immunogen: Synthetic peptide, corresponding to amino acids 670-722 of Human Rad50.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
RAD50
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RAD50
Gene Alias:
153 kDa protein, DNA repair protein RAD50, hRad50, hsRAD50, I79_004319, mRad50, Mrell, MRX complex DNA-binding subunit, N0872, NBSLD, Rad50, RAD50 2, RAD50 double strand break repair protein, RAD50 homolog (S. cerevisiae), RAD50 homolog, double strand break repair protein, RAD50 PEN, RAD502, RAD50-2, RAD50-3, Rad50l, YNL250W
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10111, 19360, 64012
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P70388, Q92878, Q9JIL8
Gene Symbols:
RAD50
Immunogen:
Synthetic peptide, corresponding to amino acids 670-722 of Human Rad50.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Maspin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SERPINB5
Gene Alias: 1110036M19Rik, AI462524, AI646751, Maspin, ovalbumin, peptidase inhibitor 5, PI5, PI-5, protease inhibitor 5, protease inhibitor 5 (maspin), serine (or cysteine) peptidase inhibitor, clade B, member 5, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, serine (or cysteine) proteinase inhibitor, clade B, member 5, serine protease inhibitor 7, serpin B5, serpin family B member 5, serpin peptidase inhibitor, clade B (ovalbumin), member 5, SERPINB5, Spi5, Spi7
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 116589, 20724, 5268
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P36952, P70124, P70564
Gene Symbols: SERPINB5
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Maspin.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Maspin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SERPINB5
Gene Alias:
1110036M19Rik, AI462524, AI646751, Maspin, ovalbumin, peptidase inhibitor 5, PI5, PI-5, protease inhibitor 5, protease inhibitor 5 (maspin), serine (or cysteine) peptidase inhibitor, clade B, member 5, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, serine (or cysteine) proteinase inhibitor, clade B, member 5, serine protease inhibitor 7, serpin B5, serpin family B member 5, serpin peptidase inhibitor, clade B (ovalbumin), member 5, SERPINB5, Spi5, Spi7
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
116589, 20724, 5268
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P36952, P70124, P70564
Gene Symbols:
SERPINB5
Immunogen:
Synthetic peptide, corresponding to amino acids 100-150 of Human Maspin.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MRE11
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Mre11
Gene Alias: ATLD, AT-like disease, DNA recombination and repair protein, double-strand break repair protein MRE11, Double-strand break repair protein MRE11A, endo/exonuclease Mre11, HNGS1, Meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A, meiotic recombination 11 homolog A (S. cerevisiae), mmMRE11A, MRE11, MRE11 double strand break repair nuclease A, MRE11 homolog 1, MRE11 homolog A, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease A, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11 meiotic recombination 11-like protein A, MRE11A, MRE11B, MRX complex nuclease subunit, NGS1, RAD58, XRS4, YM9959.06C, YMR224C
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17535, 4361, 64046
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P49959, Q61216, Q9JIM0
Gene Symbols: Mre11, Mre11a
Immunogen: Synthetic peptide, corresponding to amino acids 400-500 of Human MRE11.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MRE11
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Mre11
Gene Alias:
ATLD, AT-like disease, DNA recombination and repair protein, double-strand break repair protein MRE11, Double-strand break repair protein MRE11A, endo/exonuclease Mre11, HNGS1, Meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A, meiotic recombination 11 homolog A (S. cerevisiae), mmMRE11A, MRE11, MRE11 double strand break repair nuclease A, MRE11 homolog 1, MRE11 homolog A, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease A, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11 meiotic recombination 11-like protein A, MRE11A, MRE11B, MRX complex nuclease subunit, NGS1, RAD58, XRS4, YM9959.06C, YMR224C
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17535, 4361, 64046
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P49959, Q61216, Q9JIM0
Gene Symbols:
Mre11, Mre11a
Immunogen:
Synthetic peptide, corresponding to amino acids 400-500 of Human MRE11.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG