PIPA586931
ICAD Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586931-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA586931 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
ICAD
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DFFA
Gene Alias
A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114214, 13347, 1676
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.
O00273, O54786
Gene Symbols
DFFA
Immunogen
Synthetic peptide, corresponding to amino acids 200-250 of Human DFFA.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
- ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
- Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
- ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
- In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
- The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
- In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
- There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.
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Antigen: ICAD
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 114214, 13347, 1676
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: O00273, O54786
Gene Symbols: DFFA
Immunogen: Synthetic peptide, corresponding to amino acids 200-250 of Human DFFA.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ICAD
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
114214, 13347, 1676
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
O00273, O54786
Gene Symbols:
DFFA
Immunogen:
Synthetic peptide, corresponding to amino acids 200-250 of Human DFFA.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cathepsin D
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Ctsd
Gene Alias: CatD, Cathepsin D, Cathepsin D heavy chain, Cathepsin D light chain, CathepsinD, CD, Ceroid lipofuscinosis neuronal 10, ceroid-lipofuscinosis, neuronal 10, CLN10, CPSD, CTSD, epididymis secretory sperm binding protein Li 130P, HEL-S-130P, lysosomal aspartyl peptidase, lysosomal aspartyl protease, MGC2311, OTTHUMP00000196039, OTTHUMP00000198692
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13033, 1509, 171293
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P07339, P18242, P24268
Gene Symbols: Ctsd
Immunogen: Synthetic peptide, corresponding to amino acids 150-200 of Human CTSD.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cathepsin D
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Ctsd
Gene Alias:
CatD, Cathepsin D, Cathepsin D heavy chain, Cathepsin D light chain, CathepsinD, CD, Ceroid lipofuscinosis neuronal 10, ceroid-lipofuscinosis, neuronal 10, CLN10, CPSD, CTSD, epididymis secretory sperm binding protein Li 130P, HEL-S-130P, lysosomal aspartyl peptidase, lysosomal aspartyl protease, MGC2311, OTTHUMP00000196039, OTTHUMP00000198692
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13033, 1509, 171293
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P07339, P18242, P24268
Gene Symbols:
Ctsd
Immunogen:
Synthetic peptide, corresponding to amino acids 150-200 of Human CTSD.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Prothrombin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: F2
Gene Alias: Activation peptide fragment 1, Activation peptide fragment 2, bovine prothrombin protein, Cf2, Cf-2, coagulation factor 2, coagulation factor II, coagulation factor II (thrombin), coagulation factor II [thrombin], coagulation factor II, thrombin, F2, FII, kringle-2 domain, fragment-2, prepro-coagulation factor II, preprothrombin, prothrombin, prothrombin B-chain, prothrombin precursor, PT, RPRGL2, serine protease, THPH1, THROMBIN, Thrombin heavy chain, Thrombin light chain
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 14061, 2147, 29251
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P00734, P18292, P19221
Gene Symbols: F2
Immunogen: Synthetic peptide, corresponding to amino acids430-480 of Human Prothrombin.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Prothrombin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
F2
Gene Alias:
Activation peptide fragment 1, Activation peptide fragment 2, bovine prothrombin protein, Cf2, Cf-2, coagulation factor 2, coagulation factor II, coagulation factor II (thrombin), coagulation factor II [thrombin], coagulation factor II, thrombin, F2, FII, kringle-2 domain, fragment-2, prepro-coagulation factor II, preprothrombin, prothrombin, prothrombin B-chain, prothrombin precursor, PT, RPRGL2, serine protease, THPH1, THROMBIN, Thrombin heavy chain, Thrombin light chain
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14061, 2147, 29251
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P00734, P18292, P19221
Gene Symbols:
F2
Immunogen:
Synthetic peptide, corresponding to amino acids430-480 of Human Prothrombin.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Caspase 8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12370, 64044, 841
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: O89110, Q14790, Q9JHX4
Gene Symbols: Casp8
Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human Caspase8.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12370, 64044, 841
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
O89110, Q14790, Q9JHX4
Gene Symbols:
Casp8
Immunogen:
Synthetic peptide, corresponding to amino acids 350-400 of Human Caspase8.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG