PIPA586748

ATM Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA586748-Each-of-1 In Stock ₹ 44,705.10

PIPA586748 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

ATM

Classification

Polyclonal

Conjugate

Unconjugated

Gene

ATM

Gene Alias

AI256621, AT mutated, A-T mutated, A-T mutated homolog, AT mutated protein, AT1, ATA, Ataxia t, Ataxia telangiectasia gene mutated in human beings, ataxia telangiectasia mutated, Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, Atm, ATM (phospho S1981), ATM (pS1981), ATM (pSer1981), ATM phospho S1981, ATM phospho Ser1981, ATM serine/threonine kinase, C030026E19Rik, DKFZp781A0353, EC 2.7.1.37, MGC74674, phospho ATM, phospho S1981 ATM, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

11920, 300711, 472

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.

Q13315, Q62388

Gene Symbols

ATM

Immunogen

A synthetic peptide corresponding to residues in Human ATM.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family
  • Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer
  • The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily
  • ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1
  • The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens
  • The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases)
  • Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation
  • AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction
  • Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair
  • Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA586748

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Antigen:
ATM

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ATM

Gene Alias:
AI256621, AT mutated, A-T mutated, A-T mutated homolog, AT mutated protein, AT1, ATA, Ataxia t, Ataxia telangiectasia gene mutated in human beings, ataxia telangiectasia mutated, Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, Atm, ATM (phospho S1981), ATM (pS1981), ATM (pSer1981), ATM phospho S1981, ATM phospho Ser1981, ATM serine/threonine kinase, C030026E19Rik, DKFZp781A0353, EC 2.7.1.37, MGC74674, phospho ATM, phospho S1981 ATM, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
11920, 300711, 472

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
Q13315, Q62388

Gene Symbols:
ATM

Immunogen:
A synthetic peptide corresponding to residues in Human ATM.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA586750

--


Antigen:
TERT

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
TERT

Gene Alias:
CMM9, DKCA2, DKCB4, EST2, HEST2, hTERT, hTRT, PFBMFT1, RGD:70494}, TCS1, Telomerase catalytic subunit, telomerase reverse transcriptase, telomerase reverse transcriptase beta, telomerase-associated protein 2, TERT, tert {ECO:0000312, TP2, TR, TRT

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
21752, 301965, 7015

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
O14746, O70372, Q673L6

Gene Symbols:
TERT

Immunogen:
A synthetic peptide corresponding to residues in Human TERT.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA586752

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Antigen:
VHL

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
VHL

Gene Alias:
elongin binding protein, HRCA1, Protein G7, pVHL, RCA1, VHL, VHL1, VHL19, Vhlh, VHLp18(MEA), Von Hippel Lindau, von hippel-lindau, von Hippel-Lindau disease tumor suppressor, von Hippel-Lindau syndrome homolog, von Hippel-Lindau syndrome protein homolog, von Hippel-Lindau tumor suppressor, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
22346, 24874, 7428

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
P40337, P40338, Q64259

Gene Symbols:
VHL

Immunogen:
A synthetic peptide corresponding to residues in Human VHL.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA586753

--


Antigen:
FOXM1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
FOXM1

Gene Alias:
AA408308, AW554517, BB238854, cell growth-inhibiting gene 27 protein, FGCP, FKH L16, Fkh16, FKHL 16, FKHL16, folate hydrolase (prostate-specific membrane antigen) 1, Folate hydrolase 1, FOLH, FOLH1, Folylpoly-gamma-glutamate carboxypeptidase, forkhead box M1, forkhead box protein M1, forkhead homolog 16, Forkhead like 16, Forkhead, drosophila, homolog-like 16, forkhead-related protein FKHL16, FOXM 1, FOXM 1c, FOXM1, FOXM1B, GCP2, GCPII, GIG27, glutamate carboxylase II, glutamate carboxypeptidase 2, Glutamate carboxypeptidase II, hepatocyte nuclear factor 3 forkhead homolog 11, HFH 11, HFH11, HFH-11, HFH-11B, HNF 3, HNF3, HNF-3, HNF-3/fork-head homolog 11, INS 1, INS1, INS-1, INS-1 winged helix, Membrane glutamate carboxypeptidase, mGCP, M-phase phosphoprotein 2, MPHOSPH 2, MPHOSPH2, MPM 2, Mpm2, MPM-2 reactive phosphoprotein 2, MPP 2, MPP2, MPP-2, NAALAD1, NAALAdase, NAALADase I, N-acetylated alpha-linked acidic dipeptidase 1, N-acetylated-alpha-linked acidic dipeptidase I, PIG 29, PIG

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
14235, 2305, 58921

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.:
O08696, P97691, Q08050

Gene Symbols:
FOXM1

Immunogen:
A synthetic peptide corresponding to residues in Human FOXM1.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG