68-155-0
Tocris™ Selumetinib
Manufacturer: Tocris™
CAS Number: 606143-52-6
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Chemical Name or Material
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
Synonym
calcium sensor protein, DBS, DBSlow-density lipoprotein receptor-related protein 2, EC 1.1.2.3, EC 3.4.21.9, Glycoprotein 330, GP330, Heymann nephritis antigen homolog, low density lipoprotein receptor-related protein 2, LRP2, LRP-2, megalin
Molecular Formula
C17H15BrClFN4O3
Product Type
Inhibitor
CAS
606143-52-6
Quantity
50 mg
Formula Weight
457.68
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Apexbio Technology LLC AZD6244 (Selumetinib), 606143-52-6, MFCD11977472, 100 mg | -- | ₹ 7,120.00 | ||
Medchemexpress LLC Selumetinib | 606143-52-6 | MFCD11977472 | 10mM x 1mL | -- | ₹ 8,130.15 | ||
Medchemexpress LLC HY-50706 1g , Selumetinib CAS:606143-52-6 Purity:>98% | -- | ₹ 48,126.75 | ||
Selleck Chemical LLC Selumetinib (AZD6244) 200mg 606143-52-6 ARRY-142886 | -- | ₹ 29,583.60 | ||
Selleck Chemical LLC Selumetinib (AZD6244) 10mM/1mL 606143-52-6 ARRY-142886 | -- | ₹ 21,039.60 | ||
Selleck Chemical LLC Selumetinib (AZD6244) 50mg 606143-52-6 ARRY-142886 | -- | ₹ 15,699.60 | ||
Enzo Life Sciences Selumetinib (50mg). CAS: 606143-52-6 | -- | ₹ 14,636.05 | ||
Medchemexpress LLC HY-50706 50mg Medchemexpress, Selumetinib CAS:606143-52-6 Purity:>98% | -- | ₹ 7,382.55 | ||
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide | -- | ₹ 4,361.00 - ₹ 26,433.00 | ||
Selumetinib | -- | ₹ 5,162.00 - ₹ 1,25,668.00 |
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Description
- Selumetinib is a potent and selective MEK inhibitor (IC50 = 14 nM for MEK1, Kd = 530 nM for MEK2)
- Inhibits ERK1/2 phosphorylation (IC50 = 10 nM)
- Exhibits no activity at p38α, MKK6, EGFR, ErbB2 and ERK2
- Suppresses several cell lines containing B-Raf and Ras mutations, but displays no effect on a normal fibroblast cell lines
- Inhibits tumor growth in colorectal tumor xenograft model
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C