72-625
Tocris™ SJF 1528
Manufacturer: Tocris™
CAS Number: 2230821-38-0
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 72-625-Each-of-1 | In Stock | ₹ 42,095.52 |
72-625 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,095.52
GST (18%): ₹ 7,577.194
Total Price: ₹ 49,672.714
Chemical Name or Material
(2 S,4 R)-1-(-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity
5 mg
Molecular Formula
C55H57ClFN7O8S
CAS
2230821-38-0
Target
Active Degraders
Purity
0.98
Related Products
Description
- SJF 1528 is a potent EGFR PROTAC™ Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells)
- Also degrades HER2
- SJF 1528 comprises the EGFR inhibitor lapatinib (Cat
- No
- 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand
- Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells)
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: (2 S,4 R)-1-(-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity: 5 mg
Molecular Formula: C55H57ClFN7O8S
CAS: 2230821-38-0
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
(2 S,4 R)-1-(-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity:
5 mg
Molecular Formula:
C55H57ClFN7O8S
CAS:
2230821-38-0
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: N-(3-Fluoro-4-((7-(3-(3-(3-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic
Quantity: 5 mg
Molecular Formula: C58H65F2N7O11S
CAS: 2230821-68-6
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
N-(3-Fluoro-4-((7-(3-(3-(3-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic
Quantity:
5 mg
Molecular Formula:
C58H65F2N7O11S
CAS:
2230821-68-6
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: N-(3-Fluoro-4-((7-(4-(4-(2-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarb
Quantity: 5 mg
Molecular Formula: C59H67F2N7O11S
CAS: 2254609-27-1
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
N-(3-Fluoro-4-((7-(4-(4-(2-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarb
Quantity:
5 mg
Molecular Formula:
C59H67F2N7O11S
CAS:
2254609-27-1
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: 2-[3 '-Fluoro-5 '-[1-[2-(methylamino)-2-oxoethyl]-1 H-pyrazol-4-yl]-2,5-dioxo-2 ',3 '-dihydrospiro(imidazolidine-4,1 '-inden)-1-yl]-N-(4-fluorobenzyl)-N-(1,1,1-trifluoropropane-2-yl)acetamide
Quantity: 5 mg
Molecular Formula: C29H27F5N6O4
CAS: __
Target: Histone Acetyltransferase Inhibitors
Purity: 0.98
Chemical Name or Material:
2-[3 '-Fluoro-5 '-[1-[2-(methylamino)-2-oxoethyl]-1 H-pyrazol-4-yl]-2,5-dioxo-2 ',3 '-dihydrospiro(imidazolidine-4,1 '-inden)-1-yl]-N-(4-fluorobenzyl)-N-(1,1,1-trifluoropropane-2-yl)acetamide
Quantity:
5 mg
Molecular Formula:
C29H27F5N6O4
CAS:
__
Target:
Histone Acetyltransferase Inhibitors
Purity:
0.98