78-375
Tocris Bioscience™ JB 300
Manufacturer: Tocris Bioscience™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 78-375-Each-of-1 | In Stock | ₹ 36,757.00 |
78-375 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,757.00
GST (18%): ₹ 6,616.26
Total Price: ₹ 43,373.26
Chemical Name or Material
trans-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
Target
Active Degraders
Purity
0.98
Quantity
5 mg
Molecular Formula
C43H45ClFN7O10S
Related Products
Description
- JB 300 is a potent and selective Aurora A Degrader (PROTAC™;; DC50 = 30 nM and Dmax = 78%)
- It comprises a cereblon E3-ligase ligand Thalidomide (Cat
- No
- 0652) joined by a PEG2 linker to the Aurora A inhibitor MK-5108
- The compound depletes Aurora A in MV4-11 cell lines and exhibits no degradation of Aurora B at 10 μM
- JB 300 shows dose-dependent cytotoxicity in AML cells
- PROTAC™; is a registered trademark of Arvinas Operations, Inc., and is used under license .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: trans-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
Target: Active Degraders
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C43H45ClFN7O10S
Chemical Name or Material:
trans-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
Target:
Active Degraders
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C43H45ClFN7O10S
Chemical Name or Material: __
Target: __
Purity: __
Quantity: 1000 Units
Molecular Formula: __
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Purity:
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Quantity:
1000 Units
Molecular Formula:
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Chemical Name or Material: __
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Purity: __
Quantity: 5000 Units
Molecular Formula: __
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5000 Units
Molecular Formula:
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Chemical Name or Material: __
Target: __
Purity: __
Quantity: 500 Units
Molecular Formula: __
Chemical Name or Material:
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Target:
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Purity:
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Quantity:
500 Units
Molecular Formula:
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