69-705-TOC
Tocris™ aTAG 2139
Manufacturer: Tocris™
CAS Number: 2387510-81-6
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 69-705-TOC-Each-of-1 | In Stock | ₹ 50,374.00 |
69-705-TOC - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,374.00
GST (18%): ₹ 9,067.32
Total Price: ₹ 59,441.32
Chemical Name or Material
6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
Quantity
5 mg
Molecular Formula
C42H38N8O8
CAS
2387510-81-6
Target
TAG Degradation Platforms
Purity
98%
Related Products
Description
- aTAG 2139 is a degrader of MTH1 fusion proteins for use within the aTAG system
- Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat
- No
- 0652)
- Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%)
- Cell-permeable
- Suitable for in vitro and in vivo applications
- Negative control aTAG 2139-NEG (Cat
- No
- 7575) also available
- Mouse DMPK properties are provided in the supplementary file (see below)
- MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in
- See protocol for more information
- Custom knock-in cell lines for the dTAG and aTAG platforms are available from Bio-Techne .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
Quantity: 5 mg
Molecular Formula: C42H38N8O8
CAS: 2387510-81-6
Target: TAG Degradation Platforms
Purity: 98%
Chemical Name or Material:
6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
Quantity:
5 mg
Molecular Formula:
C42H38N8O8
CAS:
2387510-81-6
Target:
TAG Degradation Platforms
Purity:
98%
Chemical Name or Material: __
Quantity: __
Molecular Formula: __
CAS: __
Target: __
Purity: __
Chemical Name or Material:
__
Quantity:
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Molecular Formula:
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CAS:
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Chemical Name or Material: N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1 H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Quantity: 5 mg
Molecular Formula: C46H39F2N9O7
CAS: 2412985-00-1
Target: TAG Degradation Platforms
Purity: 98%
Chemical Name or Material:
N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1 H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Quantity:
5 mg
Molecular Formula:
C46H39F2N9O7
CAS:
2412985-00-1
Target:
TAG Degradation Platforms
Purity:
98%
Chemical Name or Material: __
Quantity: 100 Tests
Molecular Formula: __
CAS: __
Target: __
Purity: __
Chemical Name or Material:
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Quantity:
100 Tests
Molecular Formula:
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