Microneedle template

Description

• General description: Microneedles are a platform for transdermal drug delivery. The advantages of microneedles include the delivery of large molecules, painless and less invasive adminsitration of the active pharmaceutical ingredient (API), ease of administration, and improved drug delivery including dose, delivery rate and efficacy. Microneedies are also effective for vaccine delivery due to the abundance of immune cells in the dermis. These microneedle templates can be used to make reproducible and high quality microneedle patches for a variety of therapuetics.
• Application: Transdermal delivery of a variety to therapeutics including:Nucleic acid deliveryVaccine deliveryProtein or peptide delivery Small molecule delivery
• Features and Benefits: Microneedle templates are exclusively made for producing dissolvable microneedle patches with excellent qualitty and repeatability. These templates are made of silicone rubber which is extremely durable, and chemical and heat resistant.
• Physical properties: Microneedle template properties:Silicone TemplateMaterial: PDMSPatch Size (D): 10mm x 10mmArray Size: 6 x 6Needle Height (A): 800 µmNeedle Base (B): 250 µmNeedle Pitch (C): 500 µmLength of last microneedle cavity to the edge of the patch (F) can be calculated using the following formula: F = (patch size - [(n-1) x pitch)] / 2 where n = number of microneedles in one arraySterilization: Autoclave (optional)No. of use: repeated use if clean and stored properly
• Other Notes: Suggested instructions for use: 1. Ensure the microneedle template is clean by washing with mild soap and letting them air dry completely 2. Pipette a small quantity (50-100 µL) of the drug mixture onto the microneedle template 3. Subject the template to cenrifugal force for >60 seconds to ensure that alll microneedle cavities are completely filled. The speed and duration are proportional to the viscosity of the matrix material and the volume of microneedle cavities to fill. Complete filling can be confirmed by observing the microneedle cavities under microscope (20x). No air bubbles are present for complete filling.