NanoFabTx™-DC-Chol Lipid Mix

Description

• General description: NanoFabTx™-DC-Chol Lipid Mix; for synthesis of cationic (DC-cholesterol) liposomes is a ready-to-use nanoformulation blend for the synthesis of liposomes for drug delivery. The NanoFabTx™-DC-Chol Lipid Mix includes optimized protocols with step-by-step instructions for synthesizing cationic DC-cholesterol liposomes for drug delivery applications. The modification of the liposomes with the cationic lipid, DC-cholesterol, have numerous advantages including high gene transfection efficiency. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.
• Application: About NanoFabTx™NanoFabTx™ lipid mixes and formulation kits enable users to encapsulate a wide variety of therapuetic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ reagent kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
• Features and Benefits: A ready-to-use nanoformulation blend for the synthesis of cationic DC-cholesterol liposomes Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientistsFlexible synthesis tools to create uniform and reproducible liposomesOptimized to make liposomes around 100 nm with low polydispersityDC-Cholesterol allows for high transfection efficiency and targeted drug deliveryComprehensive protocols for liposome synthesis are included:A lipid film hydration and extrusion protocol.A microfluidics protocol using commercial platforms or syringe pumps. The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits are ready-to-use and include the microfluidic chip, fittings, and tubing required for microfluidics-based synthesis (compatible microfluidics system or syringe pump required).
• Legal Information: NANOFABTX is a trademark of Sigma-Aldrich Co. LLC