K1514
Thermo Scientific™ CellSensor™ SBE-blaA375 Cell Line
Manufacturer: Thermo Scientific™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | K1514-Each-of-1 | In Stock | ₹ 9,05,224.80 |
K1514 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 9,05,224.80
GST (18%): ₹ 1,62,940.464
Total Price: ₹ 10,68,165.264
Assay Entry
Cell-based beta lactamase reporter gene
Content And Storage
CellSensor™ SBE-bla A375 cells are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Product Line
CellSensor™
Target Entry
ALK5, ALK7, TGF beta/BMP pathway
System Type
CellSensor™
Cell State
Dividing Cells
Detection Method
Fluorescence
Quantity
1 Vial
Cell Line
A375
Druggable Target
Signaling Pathway
Related Products
Description
- Bone morphogenetic proteins (BMPs), members of the transforming growth factor beta (TGF-β) superfamily, play important roles in the development of the heart, central nervous system and cartilage
- Disruption of BMP signaling affects the body plan of the developing embryo
- BMPs propagate their signal by activating Activin receptor-like kinase (ALK), which in turn mediates the phosphorylation of R-Smads
- Phosphorylated R-Smad associates with Smad4 and then translocates to the nucleus regulating gene expression
- A375 cells are human malignant melanoma cells containing endogenous Smad signaling pathway
- SBE-bla A375 cell line was engineered to express beta-lactamase under the control of Smad binding element
- This cell line has been validated for Z' and EC50 under optimized conditions using BMP-4
- This cell line has also responded to Nodal and was tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, substrate loading time
- Additional information using various small molecule inhibitors and StealthTM RNAi is also provided.
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Assay Entry: Cell-based beta lactamase reporter gene
Content And Storage: CellSensor™ SBE-bla A375 cells are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Product Line: CellSensor™
Target Entry: ALK5, ALK7, TGF beta/BMP pathway
System Type: CellSensor™
Cell State: Dividing Cells
Detection Method: Fluorescence
Quantity: 1 Vial
Cell Line: A375
Druggable Target: Signaling Pathway
Assay Entry:
Cell-based beta lactamase reporter gene
Content And Storage:
CellSensor™ SBE-bla A375 cells are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Product Line:
CellSensor™
Target Entry:
ALK5, ALK7, TGF beta/BMP pathway
System Type:
CellSensor™
Cell State:
Dividing Cells
Detection Method:
Fluorescence
Quantity:
1 Vial
Cell Line:
A375
Druggable Target:
Signaling Pathway
Assay Entry: Cell-based beta lactamase reporter gene
Content And Storage: CellSensor™ TrkC-NFAT-bla CHO-K1 cells are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Product Line: CellSensor™
Target Entry: PKC and calcium pathway, TRKC
System Type: CellSensor™
Cell State: Dividing Cells
Detection Method: Fluorescence
Quantity: 1 Vial
Cell Line: CHO-K1
Druggable Target: Signaling Pathway
Assay Entry:
Cell-based beta lactamase reporter gene
Content And Storage:
CellSensor™ TrkC-NFAT-bla CHO-K1 cells are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Product Line:
CellSensor™
Target Entry:
PKC and calcium pathway, TRKC
System Type:
CellSensor™
Cell State:
Dividing Cells
Detection Method:
Fluorescence
Quantity:
1 Vial
Cell Line:
CHO-K1
Druggable Target:
Signaling Pathway
Assay Entry: Cell-based beta-arrestin recruitment
Content And Storage: LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.Includes:• Tango™ EDG8-blaU2OS cells• Tango™ EDG8-blaU2OS Assay Protocol• Certificate of AnalysisThe Tango™ EDG8-blaU2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Product Line: GeneBLAzer™, Tango™
Target Entry: EDG8
System Type: Tango™
Cell State: Dividing Cells
Detection Method: Fluorescence
Quantity: 8 x 106Cells
Cell Line: U2OS
Druggable Target: GPCR
Assay Entry:
Cell-based beta-arrestin recruitment
Content And Storage:
LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.Includes:• Tango™ EDG8-blaU2OS cells• Tango™ EDG8-blaU2OS Assay Protocol• Certificate of AnalysisThe Tango™ EDG8-blaU2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Product Line:
GeneBLAzer™, Tango™
Target Entry:
EDG8
System Type:
Tango™
Cell State:
Dividing Cells
Detection Method:
Fluorescence
Quantity:
8 x 106Cells
Cell Line:
U2OS
Druggable Target:
GPCR
Assay Entry: Cell-based beta-arrestin recruitment
Content And Storage: LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.Includes:• Tango™ EDG1-bla U2OS cells• Tango™ EDG1-bla U2OS Assay Protocol• Certificate of AnalysisThe Tango™ EDG1-bla U2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Product Line: Tango™
Target Entry: EDG1
System Type: Tango™
Cell State: Dividing Cells
Detection Method: Fluorescence
Quantity: 2 x 106Cells
Cell Line: U2OS
Druggable Target: GPCR
Assay Entry:
Cell-based beta-arrestin recruitment
Content And Storage:
LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.Includes:• Tango™ EDG1-bla U2OS cells• Tango™ EDG1-bla U2OS Assay Protocol• Certificate of AnalysisThe Tango™ EDG1-bla U2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Product Line:
Tango™
Target Entry:
EDG1
System Type:
Tango™
Cell State:
Dividing Cells
Detection Method:
Fluorescence
Quantity:
2 x 106Cells
Cell Line:
U2OS
Druggable Target:
GPCR