Transferrin

Description

• General description: Transferrin is a serum glycoprotein that participates in the transport of iron from absorption and storage sites to tissue cells. The iron-bound transferrin, also referred to as ferrotransferrin, binds to specific cell surface receptors on growing cells and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded.[1]
• Application: Transferrin, similar to insulin, is a component of most serum-free media formulations. The main function of transferrin is to transport iron into cells by receptor-mediated endocytosis.Transferrin from human serum has been used as a supplement in:differentiation medium[2]keratinocyte medium[3]haemogenic endothelium culture medium[4]embryoid-body medium[5]blast colony forming cell-culture medium[6]
• Physical form: Solution, 30 mg/ml in IMDM, filtered through 0.2 μm pore size membrane. Iron saturation is below 1%. This product is Apo-Transferrin.
• Preparation Note: Working concentration: 1 to 100 μg/ml
• Storage and Stability: Store at 2 to 8 °C. (lyophilizate and solution)
• Other Notes: For life science research only. Not for use in diagnostic procedures.