Eotaxin-3 human

Description

• General description: Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3.[1] This gene is localized to human chromosome 7q11.2, which codes for a protein of 71 amino acids.[2] It belongs to the small inducible cytokine subfamily A [3], which also includes eotaxin and eotaxin-2.[4]
• Biochem/physiol Actions: Eotaxin-3 is a potent attractant of eosinophils, and might be responsible for the accumulation of eosinophils in atopic diseases.[2] As it is involved in the recruitment of eosinophils in inflammatory diseases, it, along with its receptor, might have potential as therapeutic target in inflammatory disorders, such as asthma.[1] Demethylation results in increased expression of this gene, which in turn influences allergic reactions.[5] This gene is overexpressed in bullous pemphigoid (BP), which results in the accumulation of eosinophils in skin lesions, thus, contributing to the pathogenesis of BP.[4] Its expression is also elevated in the active lesions of patients with ulcerative colitis (UC) and Crohn′s disease (CD). Thus, it might play a role in the pathogenesis of UC, where its major source is colonic myofibroblasts.[6]
• Physical form: Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
• Analysis Note: The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.