R6267
RANTES human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Manufacturer: Sigma Aldrich
Synonym(S): Regulated on Activation, Normal T-cell Expressed and Secreted
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 μG | R6267-10-μG | In Stock | ₹ 35,542.20 |
R6267 - 10 μG
In Stock
Quantity
1
Base Price: ₹ 35,542.20
GST (18%): ₹ 6,397.596
Total Price: ₹ 41,939.796
biological source
human
Quality Level
100
recombinant
expressed in E. coli
Assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
1-5 ng/mL EC50
mol wt
7.8-8.7 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
Related Products
Description
- General description: Regulated on activation, normal T cell expressed and secreted (RANTES), also known as C-C motif chemokine ligand 5 (CCL5), is encoded by the gene mapped to human chromosome 17.[1] RANTES belongs to the chemokine family of proinflammatory basic polypeptides and is expressed by various hematopoietic and non-hematopoietic cell types involved in homing and migration of effector and memory T cells during acute infections.[2][3]
- Biochem/physiol Actions: Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5.[1][3] RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. A variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV -1 infection.[1][4]
- Physical form: Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
- Analysis Note: The biological activity is tested in culture using Baf/3 cells. Chemotaxis: EC50: 1-5 ng/mL
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
Flash Point(F)
35.6 °F
Flash Point(C)
2 °C
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biological source: human
Quality Level: 100
recombinant: expressed in E. coli
Assay: ≥97% (SDS-PAGE)
form: lyophilized powder
potency: 1-5 ng/mL EC50
mol wt: 7.8-8.7 kDa
packaging: pkg of 10 μg
storage condition: avoid repeated freeze/thaw cycles
technique(s): cell culture | mammalian: suitable
biological source:
human
Quality Level:
100
recombinant:
expressed in E. coli
Assay:
≥97% (SDS-PAGE)
form:
lyophilized powder
potency:
1-5 ng/mL EC50
mol wt:
7.8-8.7 kDa
packaging:
pkg of 10 μg
storage condition:
avoid repeated freeze/thaw cycles
technique(s):
cell culture | mammalian: suitable
biological source: __
Quality Level: __
recombinant: __
Assay: __
form: __
potency: __
mol wt: __
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technique(s): PCR: suitable
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technique(s):
PCR: suitable
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