Description

• Amino Acid Sequence: His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
• General description: Glucagon (GCG) peptide is secreted in response to insulin from pancreatic islets α-cells.[1]
• Application: Glucagon (GCG) has been:used as a component of hormone stock solution for preserving full biological activity of heart tissues obtained from male Sprague-Dawley rats[1]used as an infusion in phases II and III fasting king penguins to study the various lipolytic, metabolic, and hormonal responses[4]used for the stimulation of PGC-1α expression in hepatocytes[5]used to induce the expression of methionine adenosyltransferase α1 (MAT1A), which is involved in the regulation of hepatic levels of S-adenosylmethionine and the adaptive response to fasting[6]used to study its effect on stimulation of gluconeogenesis through hepatic lipolysis, mediated by inositol trisphosphate receptor 1 (INSP3R1)[7]intraperitoneally injected in mice to assess glucagon-induced Sam68 subcellular localization in vivo[8]
• Biochem/physiol Actions: Glucagon (GCG) produces elevation in contractility and the frequency of contraction in heart muscles. It activates PI3K (phosphoinositide 3-kinase) and thus, elevates glucose utilization by heart muscles.[1] In multiple mammals, though not humans, this peptide induces lipolysis, and is the major lipolytic hormone in birds. It also induces gluconeogenesis and glycogenolysis in mammals and birds.[4]
• Components: H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
• Other Notes: Lyophilized from 0.1% TFA in H2O