Lactoferrin from human milk

Description

• General description: Lactoferrin is mapped to human chromosome 3p21.31. It comprises globular lobes and undergoes post-translational modifications like phosphorylation and glycosylation.[1] Lactoferrin belongs to the lactotransferrin family and has Ser‐Lys catalytic dyad like serine proteases.[2]
• Application: Lactoferrin from human milk has been used: to test its neuroprotective effect on neuroblastoma cells and mouse mesencephalic dopaminergic cell lines MN9D [3] to test its antioxidative effect in Edible Bird′s Nest (EBN) induced toxicity in human neuroblastoma SH-SY5Y cells using oxygen radical absorbance capacity (ORAC) assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay[4]in the preparation of immobilized titanium substrate for testingMG-63 osteoblast activity[5]as a low-density lipoprotein (LDL) receptor-related protein (LRP1) ligand in vascular smooth muscle cells (VSMC)[6]
• Biochem/physiol Actions: Lactoferrin is blood-brain barrier (BBB) traversable and has therapeutic potential to regulate inflammation, immunity and apoptosis in Parkinson′s disease.[1] It promotes the expression of brain-derived neurotrophic factor (BDNF) via various signaling pathways and aids protection in motor dysfunction.[1] Lactoferrin favors osteogenic differentiation and proliferation of human adipose-derived stem cells (hADSCs).[3] It exhibits proteolytic activity on Haemophilus influenzae colonization factors.[2] Lactoferrin is also a nutraceutical and a potential marker in the pathophysiology of inflammatory bowel diseases, leukocytes[1]