P0440
Pimaricin preparation
~2.5% (γ-irradiated Pimaricin), aqueous suspension
Manufacturer: Sigma Aldrich
CAS Number: 7681-93-8
Synonym(S): Pimaricin, Tennecetin, Natamycin preparation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 20 ML | P0440-20-ML | In Stock | ₹ 36,339.53 |
P0440 - 20 ML
In Stock
Quantity
1
Base Price: ₹ 36,339.53
GST (18%): ₹ 6,541.115
Total Price: ₹ 42,880.645
form
aqueous suspension
Quality Level
200
concentration
~2.5% (γ-irradiated Pimaricin)
solubility
DMSO: soluble
density
1.0 g/mL at 20 °C (lit.)
antibiotic activity spectrum
fungiyeast
Mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C[C@@H](C)OC(=O)\C=C\[C@@]4([H])O[C@]4([H])C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2
InChI
1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Natamycin Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | MilliporeSigma Supelco | ₹ 20,619.96 | |
 | Sigma Aldrich Fine Chemicals Biosciences Pimaricin from Streptomyces chattanoogensis, >=95% (HPLC) | 7681-93-8 | MFCD00135085 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 32,491.41 | |
 | Sigma Aldrich Fine Chemicals Biosciences Pimaricin from Streptomyces chattanoogensis, >=95% (HPLC) | 7681-93-8 | MFCD00135085 | 50MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 59,960.45 | |
 | Sigma Aldrich Fine Chemicals Biosciences Pimaricin from Streptomyces chattanoogensis, >=95% (HPLC) | 7681-93-8 | MFCD00135085 | 100MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 1,04,999.23 | |
 | Natamycin | Supelco | ₹ 19,160.25 | |
| | Natamycin | Supelco | ₹ 14,429.73 | |
| | Natamycin | Sigma Aldrich | ₹ 40,756.13 | |
| | Pimaricin | Sigma Aldrich | ₹ 30,807.95 - ₹ 62,665.93 | |
| | Pimaricin preparation | Sigma Aldrich | ₹ 36,339.53 | |
| | Pimaricin | Sigma Aldrich | ₹ 30,807.95 - ₹ 62,665.93 |
Related Products
Description
- General description: This product is a saline suspension with approximately 2.5% pimaricin γ-irradiated.Pimaricin is a polyene antifungal antibiotic produced by Streptomyces natalensis from soil near Pietermaritzburg, South Africa.1 Pimaricin has antimicrobial activity similar to that of nystatin. In addition, it is active against Trichomonas vaginalis. Pimaricin is used in the treatment of candidiasis, trichomoniasis, fungal keratitis and aspergillosis. It has also been used as a food additive in some countries. In some studies, it has been shown to decrease the amount of mold upon which the Dermatophagoides pteronyssinus (house-dust mite) is dependent.2
- Application: Pimaricin is an amphoteric antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. It is used to study pimaricin biosynthesis[1] and as a fungicide in agar media[2].
- Biochem/physiol Actions: An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nystatin and filipin, pimaricin does not change the permeability of the plasma membrane.
- Preparation Note: The product can be further diluted with 0.5 M sodium chloride giving a suspension as well. The product can also be further diluted into an organic solvent such as dimethylformamide (may also be soluble in DMSO).The product and any aqueous dilutions will be suspensions and should not be sterile filtered.
- Storage and Stability: The product is not degraded by a single freeze-thaw cycle. The diluted product should be aliquoted and stored frozen.
- Other Notes: 20ml
SAFETY INFORMATION
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
form: aqueous suspension
Quality Level: 200
concentration: ~2.5% (γ-irradiated Pimaricin)
solubility: DMSO: soluble
density: 1.0 g/mL at 20 °C (lit.)
antibiotic activity spectrum: fungiyeast
Mode of action: cell membrane | interferes
storage temp.: 2-8°C
SMILES string: [H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C[C@@H](C)OC(=O)\C=C\[C@@]4([H])O[C@]4([H])C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2
InChI: 1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
form:
aqueous suspension
Quality Level:
200
concentration:
~2.5% (γ-irradiated Pimaricin)
solubility:
DMSO: soluble
density:
1.0 g/mL at 20 °C (lit.)
antibiotic activity spectrum:
fungiyeast
Mode of action:
cell membrane | interferes
storage temp.:
2-8°C
SMILES string:
[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C[C@@H](C)OC(=O)\C=C\[C@@]4([H])O[C@]4([H])C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2
InChI:
1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
form: powder
Quality Level: 200
concentration: __
solubility: __
density: __
antibiotic activity spectrum: __
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storage temp.: −20°C
SMILES string: __
InChI: __
form:
powder
Quality Level:
200
concentration:
__
solubility:
__
density:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
−20°C
SMILES string:
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InChI:
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form: buffered aqueous solution
Quality Level: 200
concentration: __
solubility: __
density: __
antibiotic activity spectrum: __
Mode of action: __
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InChI: __
form:
buffered aqueous solution
Quality Level:
200
concentration:
__
solubility:
__
density:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
__
SMILES string:
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InChI:
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form: powder
Quality Level: 200
concentration: __
solubility: __
density: 0.852 g/mL at 25 °C (lit.)
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: __
InChI: __
form:
powder
Quality Level:
200
concentration:
__
solubility:
__
density:
0.852 g/mL at 25 °C (lit.)
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
__
SMILES string:
__
InChI:
__