I9657
Ionomycin from Streptomyces conglobatus
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 56092-81-0
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | I9657-1-MG | In Stock | ₹ 24,810.90 |
| 5 MG | I9657-5-MG | In Stock | ₹ 88,645.93 |
I9657 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 24,810.90
GST (18%): ₹ 4,465.962
Total Price: ₹ 29,276.862
biological source
Streptomyces conglobatus
Quality Level
300
Assay
≥98% (HPLC)
solubility
acetonitrile: 10 mg/mL
antibiotic activity spectrum
Gram-positive bacteria
Mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O
InChI
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
InChI key
PGHMRUGBZOYCAA-ADZNBVRBSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences Ionomycin from Streptomyces conglobatus | 56092-81-0 | MFCD06798385 | 1mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 21,277.06 | |
 | Ionomycin, Free Acid, Streptomyces conglobatus in Solution | Millipore | ₹ 16,990.00 | |
 | Ionomycin from Streptomyces conglobatus | Sigma Aldrich | ₹ 24,810.90 - ₹ 88,645.93 | |
| | Ionomycin, Free Acid, Streptomyces conglobatus in Solution | Millipore | ₹ 16,990.00 | |
 | 56092-81-0 | IONOMYCIN | A2B Chem | ₹ 3,422.40 - ₹ 57,410.76 |
Related Products
Description
- Application: Ionomycin from Streptomyces conglobatus has been used:in magnesium-ionomycin treatment experimentsas a supplement in calcium-free Dulbecco′s modified Eagle medium (DMEM) for ionophore treatmentin the restimulation of peripheral blood mononuclear cells (PBMCs) to analyze cytokine production using flow cytometry (FCM)as a calcium ionophore to treat oocytes to perform intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)
- Biochem/physiol Actions: Ionomycin is a polyether antibiotic and an ionophore produced by the bacterium Streptomyces conglobatus. This Ca2+ ionophore is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons. Ionomycin has been shown to induce central demyelination, inhibit adrenal bovine TREK-1 channels, and regulate cell division of mature human B cells. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress, and intrinsic apoptosis mechanisms. It also stimulates the intracellular production of cytokines, interferon, perforin, interleukin-2 (IL-2), and IL-4 usually in conjunction with PMA.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
biological source: Streptomyces conglobatus
Quality Level: 300
Assay: ≥98% (HPLC)
solubility: acetonitrile: 10 mg/mL
antibiotic activity spectrum: Gram-positive bacteria
Mode of action: cell membrane | interferes
storage temp.: −20°C
SMILES string: C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O
InChI: 1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
InChI key: PGHMRUGBZOYCAA-ADZNBVRBSA-N
biological source:
Streptomyces conglobatus
Quality Level:
300
Assay:
≥98% (HPLC)
solubility:
acetonitrile: 10 mg/mL
antibiotic activity spectrum:
Gram-positive bacteria
Mode of action:
cell membrane | interferes
storage temp.:
−20°C
SMILES string:
C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O
InChI:
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
InChI key:
PGHMRUGBZOYCAA-ADZNBVRBSA-N
biological source: mouse
Quality Level: 200
Assay: __
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: __
InChI: __
InChI key: __
biological source:
mouse
Quality Level:
200
Assay:
__
solubility:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
__
SMILES string:
__
InChI:
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biological source: __
Quality Level: 200
Assay: __
solubility: DMF: 50 mg/mL
antibiotic activity spectrum: __
Mode of action: __
storage temp.: −20°C
SMILES string: O=C(N1OC(CI)=O)CCC1=O
InChI: 1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
InChI key: __
biological source:
__
Quality Level:
200
Assay:
__
solubility:
DMF: 50 mg/mL
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
−20°C
SMILES string:
O=C(N1OC(CI)=O)CCC1=O
InChI:
1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
InChI key:
__
biological source: rabbit
Quality Level: 300
Assay: __
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: −20°C
SMILES string: __
InChI: __
InChI key: __
biological source:
rabbit
Quality Level:
300
Assay:
__
solubility:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
−20°C
SMILES string:
__
InChI:
__
InChI key:
__