Rifaximin
Manufacturer: Sigma Aldrich
CAS Number: 80621-81-4
Synonym(S): 4-Deoxy-4′-methylpyrido[1′,2′-1,2]imidazo[5,4-c]rifamycin SV, Rifacol
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 G | R9904-1-G | In Stock | ₹ 11,853.38 |
| 5 G | R9904-5-G | In Stock | ₹ 43,808.78 |
R9904 - 1 G
In Stock
Quantity
1
Base Price: ₹ 11,853.38
GST (18%): ₹ 2,133.608
Total Price: ₹ 13,986.988
form
powder
Quality Level
100
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
red to orange
antibiotic activity spectrum
Gram-negative bacteriaGram-positive bacteria
Mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@H]([C@H]1C)C(=O)OC)c5c(nc6cc(C)ccn56)c4c3C2=O
InChI
1S/C43H51N3O11/c1-19-14-16-46-27(18-19)44-32-29-30-37(49)25(7)39-31(29)40(51)43(8,57-39)56-17-15-26(54-9)22(4)28(42(53)55-10)23(5)36(48)24(6)35(47)20(2)12-11-13-21(3)41(52)45-33(34(32)46)38(30)50/h11-18,20,22-24,26,28,35-36,47-50H,1-10H3,(H,45,52)/b12-11+,17-15+,21-13-/t20-,22+,23-,24-,26+,28+,35-,36-,43+/m1/s1
InChI key
HIYLTQREEOINNF-HTEWPBCCSA-N
Other Options
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Description
- General description: Chemical structure: macrolide
- Application: Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. It selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by a mechanism similar to rifabutin, β subunit binding. It is effective against aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is active against species of Staphylococcus, Streptococcus and Enterococcus. It is less active against species of Enterobacteriaceae. Rifaximin is a non-systemic, gastrointestinal site-specific antibiotic. It has a pyridoimidazole ring, making it non-absorbable. Rifaximin is a pregnane X receptor (PXR) activator[1].
- Biochem/physiol Actions: Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. Mode of action: selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by mechanism similar to rifabutin, β subunit binding. Antimicrobial spectrum: Aerobic and anaerobic Gram-positive and Gram-negative bacteria. Active against species of Staphylococcus, Streptococcus and Enterococcus; less active against species of Enterobacteriaceae.†
- Preparation Note: Practically insoluble in water, soluble in acetone and methanol.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place.
SAFETY INFORMATION
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
form: powder
Quality Level: 100
storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
color: red to orange
antibiotic activity spectrum: Gram-negative bacteriaGram-positive bacteria
Mode of action: protein synthesis | interferes
storage temp.: 2-8°C
SMILES string: CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@H]([C@H]1C)C(=O)OC)c5c(nc6cc(C)ccn56)c4c3C2=O
InChI: 1S/C43H51N3O11/c1-19-14-16-46-27(18-19)44-32-29-30-37(49)25(7)39-31(29)40(51)43(8,57-39)56-17-15-26(54-9)22(4)28(42(53)55-10)23(5)36(48)24(6)35(47)20(2)12-11-13-21(3)41(52)45-33(34(32)46)38(30)50/h11-18,20,22-24,26,28,35-36,47-50H,1-10H3,(H,45,52)/b12-11+,17-15+,21-13-/t20-,22+,23-,24-,26+,28+,35-,36-,43+/m1/s1
InChI key: HIYLTQREEOINNF-HTEWPBCCSA-N
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