SRP3323
R-SPONDIN-3 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
Manufacturer: Sigma Aldrich
Synonym(S): PWTSR, RSPO3, Roof plate-specific spondin-3
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 20 μG | SRP3323-20-μG | In Stock | ₹ 31,360.03 |
SRP3323 - 20 μG
In Stock
Quantity
1
Base Price: ₹ 31,360.03
GST (18%): ₹ 5,644.805
Total Price: ₹ 37,004.835
biological source
human
recombinant
expressed in CHO cells
Assay
≥95% (HPLC)≥95% (SDS-PAGE)
form
lyophilized
mol wt
26.9 kDa
packaging
pkg of 20 μg
impurities
endotoxin, tested
UniProt accession no.
Q9BXY4
shipped in
wet ice
storage temp.
−20°C
Description
- General description: The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, ?-catenin. This activity effectively activates and increases the subsequent nuclear signaling of ?-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/?-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions.
- Biochem/physiol Actions: The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues.
- Physical form: Lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 150 mM NaCl.
- Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Show Difference
biological source: human
recombinant: expressed in CHO cells
Assay: ≥95% (HPLC)≥95% (SDS-PAGE)
form: lyophilized
mol wt: 26.9 kDa
packaging: pkg of 20 μg
impurities: endotoxin, tested
UniProt accession no.: Q9BXY4
shipped in: wet ice
storage temp.: −20°C
biological source:
human
recombinant:
expressed in CHO cells
Assay:
≥95% (HPLC)≥95% (SDS-PAGE)
form:
lyophilized
mol wt:
26.9 kDa
packaging:
pkg of 20 μg
impurities:
endotoxin, tested
UniProt accession no.:
Q9BXY4
shipped in:
wet ice
storage temp.:
−20°C
biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
mol wt: 26.0 kDa
packaging: pkg of 10 μg
impurities: endotoxin, tested
UniProt accession no.: P12643
shipped in: wet ice
storage temp.: −20°C
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
mol wt:
26.0 kDa
packaging:
pkg of 10 μg
impurities:
endotoxin, tested
UniProt accession no.:
P12643
shipped in:
wet ice
storage temp.:
−20°C
biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
mol wt: 14.0 kDa
packaging: pkg of 10 μg
impurities: endotoxin, tested
UniProt accession no.: P15248
shipped in: wet ice
storage temp.: __
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
mol wt:
14.0 kDa
packaging:
pkg of 10 μg
impurities:
endotoxin, tested
UniProt accession no.:
P15248
shipped in:
wet ice
storage temp.:
__
biological source: mouse
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
mol wt: 6.0 kDa
packaging: pkg of 500 μg
impurities: endotoxin, tested
UniProt accession no.: P01133
shipped in: wet ice
storage temp.: __
biological source:
mouse
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
mol wt:
6.0 kDa
packaging:
pkg of 500 μg
impurities:
endotoxin, tested
UniProt accession no.:
P01133
shipped in:
wet ice
storage temp.:
__