8.51004
BOP
Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem®
Manufacturer: Sigma Aldrich
CAS Number: 56602-33-6
Synonym(S): BOP, Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphoniumhexafluorophosphate, Castro′s Reagent
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 G | 8.51004-25-G | In Stock | ₹ 7,830.00 |
| 100 G | 8.51004-100-G | In Stock | ₹ 25,990.00 |
8.51004 - 25 G
In Stock
Quantity
1
Base Price: ₹ 7,830.00
GST (18%): ₹ 1,409.40
Total Price: ₹ 9,239.40
Quality Level
200
product line
Novabiochem®
Assay
≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
138-145 °C
application(s)
peptide synthesis
storage temp.
2-8°C
InChI
1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate | Sigma Aldrich | ₹ 1,937.68 - ₹ 3,399.05 |
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Description
- General description: Peptide coupling reagent which suppresses enantiomerization [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]. Reduction of carboxylic acids activated with BOP provides a facile route to alcohols [16]. Novabiochem® recommends the replacement of BOP by PyBOP (for PyBOP please see 851009). The manufacture of BOP, as well as its utilization, involves the use or the formation of hexamethylphosphotriamide, the carcinogenicity and respiratory toxicity of which has been the subject of numerous reports. Associated Protocols and Technical Articles Guide to Selection of Coupling Reagents Literature references [1] B. Castro, et al. (1975) Tetrahedron Lett., 16, 1219. [2] B. Castro, et al. (1976) Synthesis, 751. [3] B. Castro, et al. (1977) Synthesis, 413. [4] B. Castro, et al. (1977) J. Chem. Res. (S), 182. [5] P. Rivaille, et al. (1980) Tetrahedron, 36, 3413. [6] D. L. Nguyen, et al. (1985) J. Chem. Soc., Perkin Trans. 1, 1025. [7] D. L. Nguyen, et al. (1987) J. Chem. Soc., Perkin Trans. 1, 1915. [8] A. Fournier, et al. (1988) Int. J. Peptide Protein Res., 31, 86 and 231. [9] J.-P. Briand, et al. (1989) Pept. Res., 2, 381. [10] A. Fournier, et al. (1989) Int. J. Peptide Protein Res., 33, 133. [11] D. L. Nguyen, et al. (1989) Biochem. Biophys. Res. Commun., 162, 1425. [12] W. K. Rule, et al. in ′Peptides 1988, Proc. 20th European Peptide Symposium′, G. Jung & E. Bayer (Eds), Walter de Gruyter, Berlin, 1989, pp. 238. [13] M. Forest, et al. (1990) Int. J. Peptide Protein Res., 35, 89. [14] R. Seyer, et al. (1990) Int. J. Peptide Protein Res., 35, 465. [15] H. Gausepohl, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium′, R. Epton (Eds), Intercept UK Ltd., Andover, 1993, pp. 387. [16] R. P. McGeary (1998) Tetrahedron Lett., 39, 3319.
- Linkage: Replaces: 01-62-0001
- Analysis Note: Color (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testAssay (HPLC, area%): ≥ 99.0 % (a/a)Solubility (0.6 mmole in 1 ml DMF): clearly soluble
- Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Sol. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Supplementary Hazards
EUH044
Storage Class Code
4.1A - Other explosive hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Quality Level: 200
product line: Novabiochem®
Assay: ≥99.0% (HPLC)
form: powder
reaction suitability: reaction type: Coupling Reactions
manufacturer/tradename: Novabiochem®
mp: 138-145 °C
application(s): peptide synthesis
storage temp.: 2-8°C
InChI: 1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1
Quality Level:
200
product line:
Novabiochem®
Assay:
≥99.0% (HPLC)
form:
powder
reaction suitability:
reaction type: Coupling Reactions
manufacturer/tradename:
Novabiochem®
mp:
138-145 °C
application(s):
peptide synthesis
storage temp.:
2-8°C
InChI:
1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1
Quality Level: 200
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mp: 188-191 °C
application(s): peptide synthesis
storage temp.: 2-8°C
InChI: __
Quality Level:
200
product line:
Novabiochem®
Assay:
≥99.0% (HPLC)
form:
powder
reaction suitability:
reaction type: Coupling Reactions
manufacturer/tradename:
Novabiochem®
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application(s):
peptide synthesis
storage temp.:
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Assay: ≥99.0% (HPLC)
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Quality Level:
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Novabiochem®
Assay:
≥99.0% (HPLC)
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powder
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reaction type: Coupling Reactions
manufacturer/tradename:
Novabiochem®
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__
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__
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200
product line:
Novabiochem®
Assay:
≥98.0% (HPLC)
form:
powder
reaction suitability:
reaction type: Coupling Reactions
manufacturer/tradename:
Novabiochem®
mp:
195-199 °C (decomposes)
application(s):
peptide synthesis
storage temp.:
15-25°C
InChI:
__