Merrifield resin LL (100-200 mesh)

Description

• General description: Merrifield resin was the standard support for the synthesis of peptide acids by Boc SPPS [1,2]. In peptide chemistry, it is now really only used in the synthesis of small to medium sized peptides, as the benzylic ester resin linkage is not completely stable towards repetitive treatment with TFA. Attachment of the C-terminal residue is generally achieved by heating the resin in DMF with the appropriate amino acid cesium salt in the presence of KI [3]; although,Me4N salts [4], sodium salts[5] in THF with Bu4NF catalysis [6] and zinc salts in EtOH have also been used [7]. Cleavage is normally effected by treatment of resin with HF or TFMSA, or by hydrogenolysis [8]. Alcohols can be released using reducing agents such as DIBAL [6] or LiBH4 [9]. Methyl esters can be produced by transesterification with methoxide [10]. Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins
• Linkage: Replaces: 01-64-0008
• Analysis Note: Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined by elemental analysis for sulfur after derivatization with KSAc): 0.40 - 1.00 mmol/gSwelling Volume (in CH₂Cl₂): lot specific resultThe polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh (75 - 150 µm)
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany