Description

• General description: Formononetin is an O-methylated isoflavone[1], a phytoestrogen.[2] It can be found in many legumes, different species of clovers primarily in Trifolium pratense L. (red clovers), and one of the main flavonoids found in Astragalus membranaceus (Huangqi).[1]
• Application: Formononetin has been used:as a reference standard to study export of multiple metabolites from Crocus sativus stigma extracts using liquid chromatography-photodiode array-high resolution mass spectrometry (LC-PDA-HRMS)[3]as phytoestrogen-mimetic isoflavones to test its antioxidant effects in a biomimetic environment using chemiluminescence method[4]as an authentic standard to test the isoflavones content level in both wild type and transgenic Medicago truncatula plant using high-performance liquid chromatography (HPLC)[5]to test its effects as a potential Aryl hydrocarbon receptor (AhR)-agonist on the restoration of skin barrier proteins for Atopic dermatitis (AD) treatment using different keratinocyte cell lines and human skin equivalent (HSE) model[6]
• Biochem/physiol Actions: Formononetin elicits antioxidant, anti-inflammatory, anti-hyperlipidemic, and cardioprotective effects.[7] It displays antidiabetic properties known to be effective against diabetic nephropathy in type 2 diabetes mellitus.[7] Formononetin is a well-known anti-cancer and chemotherapeutic agent that is used in cancer therapy.[1] It also displays antimicrobial, neuroprotective, and anti-hypertensive properties.[2]
• Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.