L-α-Lysophosphatidylcholine

Description

• Application: The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014). Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).
• Biochem/physiol Actions: 3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes [1], inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease [2].
• Other Notes: Preparation of demembranated frog sperm chromatin[3]