Description

• General description: Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane,[1] which makes up to 20% of total lipids.[2] It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup.[3]
• Application: 16:0 Cardiolipin might be suitable to assay mitochondrial fractions for CL-specific phospholipase activity.[8]
• Biochem/physiol Actions: Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy.[9] CL is essential for mitochondrial functions and apoptosis.[10] Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.[11]
• Packaging: 5 mL Amber Glass Screw Cap Vial (710333P-25mg)