Description

• General description: 15:0-18:1-d7 DG (1-pentadecanoyl-2-oleyol(d7)-sn-glycerol) is a deuterated derivative of 15:0-18:1-DG, with deuteration in the oleic acid bonded to glycerol in sn-2 position. Pentadecanoic is bonded to sn-1 position. Diacylglycerols (DAG) are neutral lipids that carry fatty acid esterification. DAG is synthesized from the catabolic cleavage of headgroups of phospholipids.[1] It is a small lipid and is membrane-associated.[2]
• Application: 15:0-18:1-d7 DG (1-pentadecanoyl-2-oleyol(d7)-sn-glycerol) has been used:as an internal standard to spike skeletal muscle samples for liquid chromatography-mass spectroscopy (LC-MS) analysis[3]as a lipid standard in mass spectroscopy for the identification of lipids in mitochondria and lipid droplets[4]in the egg yolk lipid extraction as an internal standard for mass spectroscopy analysis[5]
• Biochem/physiol Actions: Diacylglycerols (DAG) are lipid messengers that participate in metabolic events. Altered levels, especially accumulation of DAG is implicated in insulin resistance.[1] DAG serves as lipid modules for complex lipid synthesis. Protein kinase C (PKC) modulates DAG by interacting through its C1 domain. Impairment in DAG production is correlated to the pathology of Alzheimer′s disease, cancer and immune system diseases.[2]
• Packaging: 2 mL Amber Glass Sealed Ampule (791647C-1mg)
• Legal Information: LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.