867000P

KRN7000

Manufacturer: Sigma Aldrich

CAS Number: 158021-47-7

Synonym(S): α-Galactosyl Ceramide

Select a Size

Pack Size SKU Availability Price
1 MG 867000P-1-MG In Stock ₹ 37,162.23

867000P - 1 MG

₹ 37,162.23

In Stock

Quantity

1

Base Price: ₹ 37,162.23

GST (18%): ₹ 6,689.201

Total Price: ₹ 43,851.431

form

powder

packaging

pkg of 1 × 1 mg (867000P-1mg)

manufacturer/tradename

Avanti Polar Lipids

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@]([H])(CCCCCCCCCCCCCC)[C@](O)([H])[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O

InChI

1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42?,43-,44-,46+,47+,48+,49-,50+/m1/s1

InChI key

VQFKFAKEUMHBLV-VDYNBUGPSA-N

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Description

  • General description: α-Galactosyl Ceramide (KRN7000) is a high affinity glycolipid ligand for invariant natural killer T cell (iNKT).[1] It has  α-galactosyl ceramide core  and is a variant of agelasphin-9b ceramide core.[2] It is a synthetic homolog of α‐GalCer from marine sponges.[3] It comprises long fatty acyl chain (C26) and sphingosine base (C18).[4]
  • Application: α-Galactosyl Ceramide (KRN7000) has been used in the in-vitro stimulation of natural killer cells.[5] It is suitable for use as a lipid antigen in bone marrow derived cells (BMDC) and hepatocyte primary cells prior to antigen presentation assay.[6] It is also suitable for use as a ligand invariant natural killer T cell activation.[1]
  • Biochem/physiol Actions: α-Galactosyl Ceramide (KRN7000) administration results in T helper (TH0) or TH2 cytokine response.[3] it displays potent antitumor activity in various in vivo models such as B6 melanoma, colon26 adenocarcinoma and hepatic metastases.[4]
  • Packaging: 5 mL Amber Glass Screw Cap Vial (867000P-1mg)
  • Other Notes: Not available in Japan

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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form:
powder

packaging:
pkg of 1 × 1 mg (867000P-1mg)

manufacturer/tradename:
Avanti Polar Lipids

lipid type:
sphingolipids

shipped in:
dry ice

storage temp.:
−20°C

SMILES string:
O[C@]([H])(CCCCCCCCCCCCCC)[C@](O)([H])[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O

InChI:
1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42?,43-,44-,46+,47+,48+,49-,50+/m1/s1

InChI key:
VQFKFAKEUMHBLV-VDYNBUGPSA-N

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CCO[Ti](OCC)(OCC)OCC

InChI:
1S/4C2H5O.Ti/c4*1-2-3;/h4*2H2,1H3;/q4*-1;+4

InChI key:
JMXKSZRRTHPKDL-UHFFFAOYSA-N

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SMILES string:
C=CC[Si](CC=C)(CC=C)CC=C

InChI:
1S/C12H20Si/c1-5-9-13(10-6-2,11-7-3)12-8-4/h5-8H,1-4,9-12H2

InChI key:
AKRQMTFHUVDMIL-UHFFFAOYSA-N