Cytosine β-D-arabinofuranoside hydrochloride
crystalline
Manufacturer: Sigma Aldrich
CAS Number: 69-74-9
Synonym(S): 1-(β-D-Arabinofuranosyl)cytosine hydrochloride, Ara-C hydrochloride, Arabinocytidine hydrochloride, Arabinosylcytosine hydrochloride, Cytarabine hydrochloride, Cytosine arabinoside hydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 MG | C6645-25-MG | In Stock | ₹ 2,717.08 |
| 100 MG | C6645-100-MG | In Stock | ₹ 6,819.75 |
| 500 MG | C6645-500-MG | In Stock | ₹ 22,483.53 |
| 1 G | C6645-1-G | In Stock | ₹ 37,519.45 |
| 5 G | C6645-5-G | In Stock | ₹ 1,36,351.70 |
C6645 - 25 MG
In Stock
Quantity
1
Base Price: ₹ 2,717.08
GST (18%): ₹ 489.074
Total Price: ₹ 3,206.154
biological source
synthetic (inorganic)
Quality Level
200
Assay
≥99% (HPLC)
form
crystalline
mp
197-198 °C (lit.)
storage temp.
2-8°C
SMILES string
Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
InChI
1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
InChI key
KCURWTAZOZXKSJ-JBMRGDGGSA-N
Gene Information
human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-13605A 100mg Medchemexpress, Cytarabine (hydrochloride) CAS:69-74-9 Purity:>98% | Medchemexpress LLC | ₹ 5,390.28 | |
 | Sigma Aldrich Fine Chemicals Biosciences Cytosine beta-D-arabinofuranoside hydrochloride | 69-74-9 | MFCD00012839 | 100 mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 8,008.42 | |
 | Sigma Aldrich Fine Chemicals Biosciences Cytosine beta-D-arabinofuranoside hydrochloride crystalline | 69-74-9 | MFCD00012839 | 5G | Sigma Aldrich Fine Chemicals Biosciences | ₹ 1,45,383.55 | |
 | Sigma Aldrich Fine Chemicals Biosciences Cytosine beta-D-arabinofuranoside hydrochloride crystalline | 69-74-9 | MFCD00012839 | 1G | Sigma Aldrich Fine Chemicals Biosciences | ₹ 42,300.86 | |
 | Cytarabine hydrochloride | ChemScene | ₹ 941.16 - ₹ 58,180.80 |
Description
- Application: Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM)[1] and B27/neurobasal-A medium[2] to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.[3]
- Biochem/physiol Actions: Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
- Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
P201 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Classifications
Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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biological source: synthetic (inorganic)
Quality Level: 200
Assay: ≥99% (HPLC)
form: crystalline
mp: 197-198 °C (lit.)
storage temp.: 2-8°C
SMILES string: Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
InChI: 1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
InChI key: KCURWTAZOZXKSJ-JBMRGDGGSA-N
Gene Information: human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)
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