Monosialoganglioside GM2 from bovine brain
≥95% (TLC), lyophilized powder
Manufacturer: Sigma Aldrich
CAS Number: 19600-01-2
Synonym(S): Ganglioside GM2, monosialo
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | G8397-1-MG | In Stock | ₹ 86,578.35 |
G8397 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 86,578.35
GST (18%): ₹ 15,584.103
Total Price: ₹ 1,02,162.453
product name
Monosialoganglioside GM2 from bovine brain, ≥95% (TLC)
Quality Level
200
Assay
≥95% (TLC)
storage temp.
−20°C
InChI
1S/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1
InChI key
USMMPBVNWHAJBE-YMEOXFOQSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences Monosialoganglioside GM2 from bovine brain >=95% (TLC) | 19600-01-2 | MFCD00131137 | 1MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 89,148.39 | |
 | 19600-01-2 | GM2-Ganglioside | A2B Chem | ₹ 1,08,147.84 |
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Description
- Amino Acid Sequence: Cer-Glc-Gal(NeuAc)-GalNAc
- General description: Ganglioside GM2 (GM2), a monosialic ganglioside, belongs to the group of glycosphingolipids that are mostly localized to the outer leaflet of the plasma membrane. Gangliosides are amphipathic molecules containing a head group (modified by carbohydrates) with a negative charge. The carbohydrate groups vary from species to species. GM2 is predominantly expressed in the neural tissues.
- Application: Monosialoganglioside GM2 from bovine brain has been used:to study the effects of GM2 supplementation and depletion of all cellular ganglioside subspecies on neurite outgrowth and neuronal survival using canine dorsal root ganglia (DRG) neuronsas a reference standard for high-performance thin-layer chromatography (HPTLC) and as antigens for enzyme-linked immunosorbent assay (ELISA) to analyze the ganglioside signatures of human prostate cancer (CaP) cellsas a component of the reaction buffer to perform in vitro activity assay of GM1 synthase
- Biochem/physiol Actions: Ganglioside GM2 (GM2) is one of the critical components of the cell membrane and is essential for cell signaling and metabolism. Various studies show the involvement of gangliosides in cancer, serotype 1 reovirus infection, and insulin secretion and regulation. GM2 exhibits a protective role by associating with the adhesion, motility, and proliferation in tumor cells. Decreased expression of GM2 indicates extensive cancer malignancy. GM2 serves as a receptor for reovirus strain type 1 Lang (T1L). Abnormal regulation of GM2 has been observed in several diseases associated with the nervous system.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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product name: Monosialoganglioside GM2 from bovine brain, ≥95% (TLC)
Quality Level: 200
Assay: ≥95% (TLC)
storage temp.: −20°C
InChI: 1S/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1
InChI key: USMMPBVNWHAJBE-YMEOXFOQSA-N
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