Monosialoganglioside GM1 from bovine brain
≥95% (TLC), lyophilized powder, sialoglycolipid
Manufacturer: Sigma Aldrich
CAS Number: 37758-47-7
Synonym(S): Ganglioside GM1, monosialo
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | G7641-1-MG | In Stock | ₹ 16,962.78 |
| 5 MG | G7641-5-MG | In Stock | ₹ 48,658.38 |
| 10 MG | G7641-10-MG | In Stock | ₹ 84,218.50 |
G7641 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 16,962.78
GST (18%): ₹ 3,053.30
Total Price: ₹ 20,016.08
product name
Monosialoganglioside GM1 from bovine brain, ≥95%, lyophilized powder
Quality Level
300
Assay
≥95%
form
lyophilized powder
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCCCCCCCCC(=O)N[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@@]5(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O5)[C@H](O)[C@H](O)CO)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H](O)\C=C\CCCCCCCCCCCCCCC
InChI
1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1
InChI key
CNLVNZJJSHZYAS-ALSOZVJRSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Enzo Life Sciences Ganglioside GM1. sodium salt (bovine brain) (1mg). CAS: 37758-47-7 | Enzo Life Sciences | ₹ 8,757.07 | |
 | Sigma Aldrich Fine Chemicals Biosciences Monosialoganglioside GM1 from bovine brain >=95%, lyophilized powder | 37758-47-7 | 10MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 1,04,999.23 | |
 | Sigma Aldrich Fine Chemicals Biosciences Monosialoganglioside GM1 from bovine brain >=95%, lyophilized powder | 37758-47-7 | 1MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 13,101.80 | |
| | Monosialoganglioside GM1 from bovine brain | Sigma Aldrich | ₹ 16,638.03 | |
 | Ganglioside GM1, Ammonium Salt, Bovine Brain | Sigma Aldrich | ₹ 10,800.01 | |
 | 37758-47-7 | GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE | A2B Chem | ₹ 4,620.24 |
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Description
- Amino Acid Sequence: Cer-Glc-Gal(NeuAc)-GalNAc-Gal
- General description: Monosialoganglioside GM1 is a major sialoglycolipid of neuronal membranes.
- Application: Monosialoganglioside GM1 from bovine brain has been used:in GM1 capture enzyme-linked immunosorbent assay (ELISA)for the quantification of cholera toxin B subunit (CTB)-p277 protein accumulationfor Escherichia coli heat-labile enterotoxin (LT-B) detectionto determine the affinity of the GM1-ganglioside receptor for the plant-derived Escherichia coli heat-labile toxin LTK63 protein
- Biochem/physiol Actions: Monosialoganglioside GM1 maintains calcium homeostasis, neurotrophic factor signaling, membrane integrity, and α-synuclein aggregation. It binds to the cholera toxin B subunit, leading to the activation of adenylate cyclase in a wide variety of cell types. The binding of cholera toxin to membrane-associated monosialoganglioside GM1 causes the translocation of A subunit of cholera toxin to the cell interior for the catalysis of ADP ribosylation. In addition, the binding of cholera toxin to monosialoganglioside GM1 causes translocation of nuclear factor (NF)-kB and activation of dendritic cells. Monosialoganglioside GM1 is effective in treating cerebral ischemia and dementia, stroke, and spinal cord injury in several in vivo and in vitro model systems. Accumulation of GM1, due to defective acid hydrolases, leads to GM1 gangliosidosis, which is a lethal lysosomal disease. It was also found to have a regulatory role in the formation of neurotoxic β-amyloid fibrils associated with Alzheimer′s disease and possible involvement in the pathogenesis of demyelination in relapsing-remitting multiple sclerosis.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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product name: Monosialoganglioside GM1 from bovine brain, ≥95%, lyophilized powder
Quality Level: 300
Assay: ≥95%
form: lyophilized powder
storage temp.: −20°C
SMILES string: CCCCCCCCCCCCCCCCCCCC(=O)N[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@@]5(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O5)[C@H](O)[C@H](O)CO)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H](O)\C=C\CCCCCCCCCCCCCCC
InChI: 1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1
InChI key: CNLVNZJJSHZYAS-ALSOZVJRSA-N
product name: __
Quality Level: 200
Assay: ≥90% gibberellin A3 basis (of total gibberellins.)
form: __
storage temp.: __
SMILES string: C[C@]12[C@@H](O)C=C[C@@]3(OC1=O)[C@@H]4CC[C@]5(O)C[C@]4(CC5=C)[C@H]([C@H]23)C(O)=O
InChI: 1S/C19H22O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h4,6,10-13,20,24H,1,3,5,7-8H2,2H3,(H,21,22)/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1
InChI key: IXORZMNAPKEEDV-OBDJNFEBSA-N
product name: __
Quality Level: 300
Assay: __
form: liquid
storage temp.: −20°C
SMILES string: __
InChI: __
InChI key: __