SMB00376
CDDO Methyl Ester
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 218600-53-4
Synonym(S): 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester, Bardoxolone Methyl, CDDO-Me
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 MG | SMB00376-10-MG | In Stock | ₹ 14,451.38 |
| 100 MG | SMB00376-100-MG | In Stock | ₹ 50,184.70 |
SMB00376 - 10 MG
In Stock
Quantity
1
Base Price: ₹ 14,451.38
GST (18%): ₹ 2,601.248
Total Price: ₹ 17,052.628
Quality Level
200
Assay
≥98% (HPLC)
form
powder
application(s)
metabolomicsvitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI
1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key
WPTTVJLTNAWYAO-KPOXMGGZSA-N
Gene Information
human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ CDDO-Me | Tocris Bioscience™ | -- | |
 | Selleck Chemical LLC Bardoxolone Methyl 25mg 218600-53-4 RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me | Selleck Chemical LLC | ₹ 15,092.78 | |
 | Medchemexpress LLC HY-13324 50mg Medchemexpress, Bardoxolone methyl CAS:218600-53-4 Purity:>98% | Medchemexpress LLC | ₹ 8,983.80 | |
| | Sigma Aldrich Fine Chemicals Biosciences CDDO Methyl Ester >=98% (HPLC) | 218600-53-4 | MFCD11983137 | 100MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 55,032.19 | |
 | Bardoxolone methyl | ChemScene | ₹ 2,737.92 - ₹ 46,202.40 | |
 | 218600-53-4 | BARDOXOLONE METHYL | A2B Chem | ₹ 2,652.36 - ₹ 43,122.24 |
Description
- General description: CDDO-Me is a synthetic triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties.[1] It is derived from the natural product oleanic acid.[2]
- Application: CDDO Methyl Ester has been used to test its effect on hepatocyte membrane transporters (HMTs) regulation and mitigation of cholestasis in hepatic ischemia-reperfusion injury (IRI).[3] It has also been used activator of NF E2 Related Factor 2 (NRF2) to study its role in preventing cell death in melanoma cells.[4]
- Biochem/physiol Actions: CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents.[5] CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.[5]
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 200
Assay: ≥98% (HPLC)
form: powder
application(s): metabolomicsvitamins, nutraceuticals, and natural products
storage temp.: −20°C
SMILES string: CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI: 1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key: WPTTVJLTNAWYAO-KPOXMGGZSA-N
Gene Information: human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)
Quality Level:
200
Assay:
≥98% (HPLC)
form:
powder
application(s):
metabolomicsvitamins, nutraceuticals, and natural products
storage temp.:
−20°C
SMILES string:
CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI:
1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key:
WPTTVJLTNAWYAO-KPOXMGGZSA-N
Gene Information:
human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)
Quality Level: 200
Assay: ≥98% (HPLC)
form: powder
application(s): metabolomicsvitamins, nutraceuticals, and natural products
storage temp.: 2-8°C
SMILES string: OC1=C(OC)C=C2CC[N+](C)(C)[C@@]3([H])CC4=CC=C(OC)C(O)=C4C1=C32
InChI: 1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1
InChI key: YLRXAIKMLINXQY-ZDUSSCGKSA-O
Gene Information: __
Quality Level:
200
Assay:
≥98% (HPLC)
form:
powder
application(s):
metabolomicsvitamins, nutraceuticals, and natural products
storage temp.:
2-8°C
SMILES string:
OC1=C(OC)C=C2CC[N+](C)(C)[C@@]3([H])CC4=CC=C(OC)C(O)=C4C1=C32
InChI:
1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1
InChI key:
YLRXAIKMLINXQY-ZDUSSCGKSA-O
Gene Information:
__
Quality Level: 200
Assay: ≥99% (HPLC)
form: powder
application(s): __
storage temp.: −20°C
SMILES string: NC(C1=CC(CCC)=NC=C1)=S
InChI: 1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
InChI key: VRDIULHPQTYCLN-UHFFFAOYSA-N
Gene Information: __
Quality Level:
200
Assay:
≥99% (HPLC)
form:
powder
application(s):
__
storage temp.:
−20°C
SMILES string:
NC(C1=CC(CCC)=NC=C1)=S
InChI:
1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
InChI key:
VRDIULHPQTYCLN-UHFFFAOYSA-N
Gene Information:
__
Quality Level: 200
Assay: ≥99% (HPLC)
form: powder
application(s): metabolomicsvitamins, nutraceuticals, and natural products
storage temp.: 2-8°C
SMILES string: COc1cc(O)c(C\C=C(\C)C)c2OC(CC(=O)c12)c3ccc(O)cc3
InChI: 1S/C21H22O5/c1-12(2)4-9-15-16(23)10-19(25-3)20-17(24)11-18(26-21(15)20)13-5-7-14(22)8-6-13/h4-8,10,18,22-23H,9,11H2,1-3H3
InChI key: YKGCBLWILMDSAV-UHFFFAOYSA-N
Gene Information: __
Quality Level:
200
Assay:
≥99% (HPLC)
form:
powder
application(s):
metabolomicsvitamins, nutraceuticals, and natural products
storage temp.:
2-8°C
SMILES string:
COc1cc(O)c(C\C=C(\C)C)c2OC(CC(=O)c12)c3ccc(O)cc3
InChI:
1S/C21H22O5/c1-12(2)4-9-15-16(23)10-19(25-3)20-17(24)11-18(26-21(15)20)13-5-7-14(22)8-6-13/h4-8,10,18,22-23H,9,11H2,1-3H3
InChI key:
YKGCBLWILMDSAV-UHFFFAOYSA-N
Gene Information:
__