Nigericin sodium salt
from Streptomyces hygroscopicus, ≥98% (HPLC), solution, polyether ionophore
Manufacturer: Sigma Aldrich
CAS Number: 28643-80-3
Synonym(S): 3B2-6379, Antibiotic K178, Antibiotic X464, Azalomycin M, HE331800, Helexin C, Polyetherin A, sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 ML | SML1779-1-ML | In Stock | ₹ 11,885.85 |
SML1779 - 1 ML
In Stock
Quantity
1
Base Price: ₹ 11,885.85
GST (18%): ₹ 2,139.453
Total Price: ₹ 14,025.303
product name
Nigericin sodium salt Ready Made Solution, 5 mg/mL (DMSO:ethanol 1:1)
biological source
Streptomyces hygroscopicus
Quality Level
200
form
solution
concentration
5 mg/mL (DMSO:ethanol 1:1)
antibiotic activity spectrum
Gram-positive bacteria
Mode of action
cell membrane | interferes
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
Related Products
Description
- Biochem/physiol Actions: Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). Nigericin transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na+ and thus, disrupts membrane potential and stimulates ATPase activity in mitochondria. Nigericin kills bacteria by facilitating the diffusion of ions across membranes.Low concentration (0.5 μM) of Nigericin rapidly decreases pHi, causing stimulation of PG production 1.5- to 2-fold in cerebral microvascular endothelial cells and arresting of DNA synthesis in Erlich acites carcinoma cells. Treatment of Hela cells, after entry of poliovirus, with nigericin, prevents the inhibition of host protein synthesis by poliovirus. Nigericin is also widely used in studies of the consequences of changes in membrane potential in variable systems.
- Preparation Note: Nigericin sodium salt ready made solution is provided at 6.7 mM concentration. The solution can be further diluted with a desired solvent to a working concentration (0.5-10 μM).
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3
WGK
WGK 2
Flash Point(F)
78.8 °F
Flash Point(C)
26 °C
Compare Similar Items
Show Difference
product name: Nigericin sodium salt Ready Made Solution, 5 mg/mL (DMSO:ethanol 1:1)
biological source: Streptomyces hygroscopicus
Quality Level: 200
form: solution
concentration: 5 mg/mL (DMSO:ethanol 1:1)
antibiotic activity spectrum: Gram-positive bacteria
Mode of action: cell membrane | interferes
shipped in: ambient
storage temp.: 2-8°C
InChI: 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
product name: __
biological source: __
Quality Level: 400
form: __
concentration: __
antibiotic activity spectrum: __
Mode of action: __
shipped in: __
storage temp.: __
InChI: __
product name: __
biological source: __
Quality Level: 400
form: __
concentration: __
antibiotic activity spectrum: __
Mode of action: __
shipped in: __
storage temp.: __
InChI: __