Description

• General description: Tetramethylammonium binds AT-rich DNA polymers while concomitantly abolishing the preferential melting of AT versus GC base pairs. It is supplied as a 0.2 μm filtered solution in 18 megohm water.
• Application: Tetramethylammonium chloride solution (TMAC) has been used:in the preparation of hybridization cocktail for array hybridization and scanningin next-generation sequencing (NGS), and genome-wide unbiased identification of double-stranded breaks enabled by sequencing (GUIDE-seq) library preparationin the preparation of TMAC buffer and bead hybridization mixture for hybridization and detection