901830
Pomalidomide-PEG4-NH2 hydrochloride
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): 14-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 901830-50-MG | In Stock | ₹ 60,460.00 |
901830 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 60,460.00
GST (18%): ₹ 10,882.80
Total Price: ₹ 71,342.80
ligand
pomalidomide
Assay
≥95%
form
powder or crystals
mp
98-109 °C
storage temp.
2-8°C
SMILES string
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCN)=O)=O)NC1=O.Cl
Related Products
Description
- Application: Protein degrader builiding block Pomalidomide-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: pomalidomide
Assay: ≥95%
form: powder or crystals
mp: 98-109 °C
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCN)=O)=O)NC1=O.Cl
ligand:
pomalidomide
Assay:
≥95%
form:
powder or crystals
mp:
98-109 °C
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCN)=O)=O)NC1=O.Cl
ligand: pomalidomide
Assay: __
form: powder
mp: __
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl
ligand:
pomalidomide
Assay:
__
form:
powder
mp:
__
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl
ligand: pomalidomide
Assay: ≥98%
form: powder
mp: __
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl
ligand:
pomalidomide
Assay:
≥98%
form:
powder
mp:
__
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl
ligand: pomalidomide
Assay: ≥95%
form: powder or crystals
mp: __
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCCOCCOCCOCC#C)=O)=O)NC1=O
ligand:
pomalidomide
Assay:
≥95%
form:
powder or crystals
mp:
__
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCCOCCOCCOCC#C)=O)=O)NC1=O