930555

Pomalidomide-piperazine-acetic acid

≥95%

Manufacturer: Sigma Aldrich

CAS Number: 2591180-39-9

Synonym(S): 2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)acetic acid, {4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}acetic acid

Select a Size

Pack Size SKU Availability Price
50 MG 930555-50-MG In Stock ₹ 18,670.00

930555 - 50 MG

₹ 18,670.00

In Stock

Quantity

1

Base Price: ₹ 18,670.00

GST (18%): ₹ 3,360.60

Total Price: ₹ 22,030.60

ligand

pomalidomide

Quality Level

100

Assay

≥95%

form

powder

functional group

carboxylic acid

storage temp.

2-8°C

SMILES string

O=C(O)CN1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1

Other Options

Image Product Name Manufacturer Price Range
BL12724
2591180-39-9 | 2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)acetic acid
A2B Chem ₹ 28,491.48 - ₹ 2,96,037.60

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Description

  • Application: Pomalidomide-piperazine-acetic acid is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with amine linkers due to the presence of a carboxyl group via peptide coupling reactions. A basic building block for development of a protein degrader library.Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Protein Degrader Building Blocks
  • Other Notes: Targeted Protein Degradation by Small Molecules Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERGSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs

SAFETY INFORMATION

Pictograms

GHS08

Signal Word

Danger

Hazard Statements

H360D

Precautionary Statements

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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≥95%

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carboxylic acid

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2-8°C

SMILES string:
O=C(O)CN1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1

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O=C(O)C1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1

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