465110

Tocris Bioscience™ JW 67

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>97%

Product Type

JW 67

Inhibitors

JW 67

Quantity

10 mg

Molecular Weight (g/mol)

394.38

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Description

  • Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation
  • Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways
  • Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).

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