SML1184
OF-1
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 919973-83-4
Synonym(S): 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML1184-5-MG | In Stock | ₹ 14,970.98 |
SML1184 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 14,970.98
GST (18%): ₹ 2,694.776
Total Price: ₹ 17,665.756
Quality Level
100
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1
InChI
1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChI key
YUNQZQREIHWDQT-UHFFFAOYSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ OF 1 | Fischer Scientific | -- | |
| | Tocris Bioscience™ OF 1 | Fischer Scientific | ₹ 22,430.41 | |
| | Tocris Bioscience™ OF 1 | Fischer Scientific | ₹ 91,011.88 | |
 | 919973-83-4 | Of-1 | A2B Chem | ₹ 1,711.20 - ₹ 33,368.40 |
Related Products
Description
- Biochem/physiol Actions: OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1 on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
- Features and Benefits: OF-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 5 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1
InChI: 1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChI key: YUNQZQREIHWDQT-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 5 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1
InChI:
1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChI key:
YUNQZQREIHWDQT-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to light brown
solubility: DMSO: 10 mg/mL, clear
storage temp.: 2-8°C
SMILES string: __
InChI: 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
InChI key: GMCOGJQJFDQZCP-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to light brown
solubility:
DMSO: 10 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
__
InChI:
1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
InChI key:
GMCOGJQJFDQZCP-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to light brown
solubility: DMSO: 20 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
InChI: 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
InChI key: DMIDPTCQPIJYFE-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to light brown
solubility:
DMSO: 20 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
InChI:
1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
InChI key:
DMIDPTCQPIJYFE-UHFFFAOYSA-N
Quality Level: 200
Assay: ≥98% (HPLC)
form: powder
color: yellow to yellow-orange
solubility: DMSO: soluble 5 mg/mL
storage temp.: −20°C
SMILES string: __
InChI: __
InChI key: __
Quality Level:
200
Assay:
≥98% (HPLC)
form:
powder
color:
yellow to yellow-orange
solubility:
DMSO: soluble 5 mg/mL
storage temp.:
−20°C
SMILES string:
__
InChI:
__
InChI key:
__