SML0974
(+/-)-JQ1
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 1268524-69-1
Synonym(S): N-(2′,5′-Dimethoxy[1,1′-biphenyl]-4-yl)-3-fluoro-4-pyridinecarboxamide, (+/-)-SGCBD01, [(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML0974-5-MG | In Stock | ₹ 23,133.03 |
| 25 MG | SML0974-25-MG | In Stock | ₹ 75,082.20 |
SML0974 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 23,133.03
GST (18%): ₹ 4,163.945
Total Price: ₹ 27,296.975
Quality Level
100
Assay
≥98% (HPLC)
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=NC2CC(OC(C)(C)C)=O
InChI
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
InChI key
DNVXATUJJDPFDM-UHFFFAOYSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences (+/-)-JQ1 >=98% (HPLC) | 1268524-69-1 | MFCD23726614 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 22,010.31 | |
 | 1268524-69-1 | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester | A2B Chem | ₹ 4,962.48 - ₹ 30,031.56 |
Related Products
Description
- Application: (±)-JQ1 has been used to study its effect on adipogenesis, by analyzing the its impact on the regulation of genes involved in this process especially peroxisome proliferator-activated receptor (PPAR-g), the CCAAT/enhancer-binding protein (C/EBPa) and, STAT5A and B.[1] JQ1 has been used in drug binding assays as a chemical inhibitor of BRD4 to study the CRBN’s substrate recruiting function in mouse and human.[2]
- Biochem/physiol Actions: (±)-JQ1 is a Brd4 inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.[3]
- Features and Benefits: (+/-) JQ-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
- Other Notes: JQ1 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JQ1 probe summary on the Chemical Probes Portal website.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
color: white to beige
solubility: DMSO: 2 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=NC2CC(OC(C)(C)C)=O
InChI: 1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
InChI key: DNVXATUJJDPFDM-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
drug control:
regulated under CDSA - not available from Sigma-Aldrich Canada
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=NC2CC(OC(C)(C)C)=O
InChI:
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
InChI key:
DNVXATUJJDPFDM-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
drug control: __
color: white to beige
solubility: DMSO: 5 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: FC(CC1)(F)CCN1C2=NC(NC3CCN(C(C)C)CC3)=C4C(C=C(OCCCN5CCCC5)C(OC)=C4)=N2
InChI: 1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
InChI key: RNAMYOYQYRYFQY-UHFFFAOYSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
drug control:
__
color:
white to beige
solubility:
DMSO: 5 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
FC(CC1)(F)CCN1C2=NC(NC3CCN(C(C)C)CC3)=C4C(C=C(OCCCN5CCCC5)C(OC)=C4)=N2
InChI:
1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
InChI key:
RNAMYOYQYRYFQY-UHFFFAOYSA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
drug control: __
color: white to beige
solubility: DMSO: 20 mg/mL, clear
storage temp.: −20°C
SMILES string: BrC1=CN([C@@H]2O[C@H](CN(CCCNC(NC3=CC=C(C(C)(C)C)C=C3)=O)C(C)C)[C@@H](O)[C@H]2O)C4=C1C(N)=NC=N4
InChI: 1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
InChI key: IQCKJUKAQJINMK-HUBRGWSESA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
drug control:
__
color:
white to beige
solubility:
DMSO: 20 mg/mL, clear
storage temp.:
−20°C
SMILES string:
BrC1=CN([C@@H]2O[C@H](CN(CCCNC(NC3=CC=C(C(C)(C)C)C=C3)=O)C(C)C)[C@@H](O)[C@H]2O)C4=C1C(N)=NC=N4
InChI:
1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
InChI key:
IQCKJUKAQJINMK-HUBRGWSESA-N
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
drug control: __
color: white to beige
solubility: DMSO: 10 mg/mL, clear
storage temp.: 2-8°C
SMILES string: CC1=C(C(C)=NO1)C2=CC=C3C(N=C(CCC4=CC=C(OC)C(Cl)=C4)N3C[C@@H](N5CCOCC5)C)=C2
InChI: 1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
InChI key: GEPYBHCJBORHCE-SFHVURJKSA-N
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
drug control:
__
color:
white to beige
solubility:
DMSO: 10 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
CC1=C(C(C)=NO1)C2=CC=C3C(N=C(CCC4=CC=C(OC)C(Cl)=C4)N3C[C@@H](N5CCOCC5)C)=C2
InChI:
1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
InChI key:
GEPYBHCJBORHCE-SFHVURJKSA-N