7076321
Thermo Scientific™ Vivid™ DBOMF Substrate
Vivid™ Substrates are blocked dyes that yield a minimal fluorescence signal until oxidation occurs.
Manufacturer: Fischer Scientific
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Content And Storage
Vivid™ CYP450 Screening kits include:• Vivid™ CYP450 Fluorogenic substrates (also available separately)• BACULOSOMES™ CYP450 reagents• Fluorescent standards• NADPH-regeneration systemStore reaction buffers at +4°C or room temperature. Store BACULOSOMES™, the NADPH-regeneration system, and NADP+ at -80°C. Store the Vivid™ substrates and standards at +4°C, protected from light. (For long-term storage, resuspend in organic solvent and keep at -20°C.)
Product Line
VIVID™
Substrate Properties
Chemical Substrate
Shipping Condition
Approved for shipment on Wet or Dry Ice
Detection Method
Fluorescence
Substrate
DBOMF
Substrate Type
Cytochrome P450 Substrate
Related Products
Description
- Vivid™ Substrates are blocked dyes that yield a minimal fluorescence signal until oxidation occurs
- Cytochrome P450 metabolism at either of two potential oxidation sites releases the highly fluorescent product
- They have superior fluorescence, solubility, and kinetic properties compared to conventional fluorogenic probes
- This results in higher sensitivity, greater signal-to-noise ratio, and better assay reproducibility
- When used in combination with CYP450 BACULOSOMES™ Plus Reagents as part of the Vivid™ CYP450 Screening Kits, the Vivid™ Substrates enable rapid, robust detection of cytochrome P450 inhibitors
- This particular substrate (Vivid ™ DBOMF Substrate) yields a product that emits a green fluorescence
- More About Vivid™ CYP450 Screening Kits Vivid™ CYP450 Screening Kits are high-throughput fluorescence-based assays for detection of enzyme-drug interactions and CYP450 inhibition
- Vivid™ CYP450 Screening Kits include Vivid™ Substrate, Vivid™ Fluorescent Standard, reaction buffer, Vivid™ Regeneration System, NADP+, and CYP450 BACULOSOMES™ Plus Reagent
- CYP450 BACULOSOMES™ Plus Reagents are microsomes prepared from insect cells expressing a human CYP450 isozyme and human cytochrome P450 reductase
- CYP450 BACULOSOMES™ Plus Reagents offer a distinct advantage over human liver microsomes in that only one CYP450 isozyme is expressed, thereby preventing metabolism by other CYP450s
- Applications High-throughput screening of enzyme-drug interactions Compound profiling for drug inhibition of cytochrome P450 isozymes Generation of predictive SAR models to guide compound acquisition
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Content And Storage: Vivid™ CYP450 Screening kits include:• Vivid™ CYP450 Fluorogenic substrates (also available separately)• BACULOSOMES™ CYP450 reagents• Fluorescent standards• NADPH-regeneration systemStore reaction buffers at +4°C or room temperature. Store BACULOSOMES™, the NADPH-regeneration system, and NADP+ at -80°C. Store the Vivid™ substrates and standards at +4°C, protected from light. (For long-term storage, resuspend in organic solvent and keep at -20°C.)
Product Line: VIVID™
Substrate Properties: Chemical Substrate
Shipping Condition: Approved for shipment on Wet or Dry Ice
Detection Method: Fluorescence
Substrate: DBOMF
Substrate Type: Cytochrome P450 Substrate
Content And Storage:
Vivid™ CYP450 Screening kits include:• Vivid™ CYP450 Fluorogenic substrates (also available separately)• BACULOSOMES™ CYP450 reagents• Fluorescent standards• NADPH-regeneration systemStore reaction buffers at +4°C or room temperature. Store BACULOSOMES™, the NADPH-regeneration system, and NADP+ at -80°C. Store the Vivid™ substrates and standards at +4°C, protected from light. (For long-term storage, resuspend in organic solvent and keep at -20°C.)
Product Line:
VIVID™
Substrate Properties:
Chemical Substrate
Shipping Condition:
Approved for shipment on Wet or Dry Ice
Detection Method:
Fluorescence
Substrate:
DBOMF
Substrate Type:
Cytochrome P450 Substrate
Content And Storage: Vivid™ CYP450 Screening kits include:• Vivid™ CYP450 Fluorogenic substrates (also available separately)• BACULOSOMES™ CYP450 reagents• Fluorescent standards• NADPH-regeneration systemStore reaction buffers at +4°C or room temperature. Store BACULOSOMES™, the NADPH-regeneration system, and NADP+ at -80°C. Store the Vivid™ substrates and standards at +4°C, protected from light. (For long-term storage, resuspend in organic solvent and keep at -20°C.)
Product Line: VIVID™
Substrate Properties: Chemical Substrate
Shipping Condition: Approved for shipment on Wet or Dry Ice
Detection Method: Fluorescence
Substrate: EOMCC
Substrate Type: Cytochrome P450 Substrate
Content And Storage:
Vivid™ CYP450 Screening kits include:• Vivid™ CYP450 Fluorogenic substrates (also available separately)• BACULOSOMES™ CYP450 reagents• Fluorescent standards• NADPH-regeneration systemStore reaction buffers at +4°C or room temperature. Store BACULOSOMES™, the NADPH-regeneration system, and NADP+ at -80°C. Store the Vivid™ substrates and standards at +4°C, protected from light. (For long-term storage, resuspend in organic solvent and keep at -20°C.)
Product Line:
VIVID™
Substrate Properties:
Chemical Substrate
Shipping Condition:
Approved for shipment on Wet or Dry Ice
Detection Method:
Fluorescence
Substrate:
EOMCC
Substrate Type:
Cytochrome P450 Substrate
Content And Storage: __
Product Line: Gibco™
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Shipping Condition: Room Temperature
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Gibco™
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Room Temperature
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