BDB556449
BD Ac-DEVD-AMC Caspase-3 Substrate
Manufacturer: BD
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Form
Lyophilized
Substrate Type
Caspase Substrate
Molecular Weight (g/mol)
694
Substrate Quantity
1mg
For Use With (Application)
For Caspase-3, fluorescence quantitation, used in protease assays
Includes
Amino acid sequence of the PARP cleavage site at Asp 216
Storage Requirements
-20°C
Related Products
Description
- Members of the ICE/CED-3 cysteine protease family have key roles in inflammation and mammalian apoptosis
- The ICE family member Caspase-3 (also known as CPP32, Yama, apopain) is activated early in apoptosis and appears to be involved in the proteolysis of several important molecules, including poly (ADP ribose) polymerase (PARP)
- Activated Caspase-3 cleaves PARP from its 116 kDa to an 85 kDa residual fragment
- The cleavage site in PARP is C-terminal to Asp-216
- The upstream sequence of the cleavage site, DEVD (Asp-Glu-Val-Asp), is utilized as a basis for the highly specific Caspase-3 substrate, Ac (N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin)
- Format: Purified Storage buffer: Lyophilized powder Functional assay
SAFETY INFORMATION
- ShelfLife : 1 to 2 Months
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Form: Lyophilized
Substrate Type: Caspase Substrate
Molecular Weight (g/mol): 694
Substrate Quantity: 1mg
For Use With (Application): For Caspase-3, fluorescence quantitation, used in protease assays
Includes: Amino acid sequence of the PARP cleavage site at Asp 216
Storage Requirements: -20°C
Form:
Lyophilized
Substrate Type:
Caspase Substrate
Molecular Weight (g/mol):
694
Substrate Quantity:
1mg
For Use With (Application):
For Caspase-3, fluorescence quantitation, used in protease assays
Includes:
Amino acid sequence of the PARP cleavage site at Asp 216
Storage Requirements:
-20°C
Form: __
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Storage Requirements: 4°C
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Includes:
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Storage Requirements:
4°C
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Form:
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Form: Purified
Substrate Type: __
Molecular Weight (g/mol): 502.5
Substrate Quantity: __
For Use With (Application): Functional assay
Includes: __
Storage Requirements: __
Form:
Purified
Substrate Type:
__
Molecular Weight (g/mol):
502.5
Substrate Quantity:
__
For Use With (Application):
Functional assay
Includes:
__
Storage Requirements:
__