7250146
Tocris Bioscience™ ABT 263
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
Manufacturer: Fischer Scientific
CAS Number: 923564-51-6
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Chemical Name or Material
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Target
Bcl-2 Family Inhibitors
Purity
0.98
CAS
923564-51-6
Molecular Formula
C47H55ClF3N5O6S3
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Description
- ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (Ki values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively)
- ABT 263 induces G1/G0 phase arrest, apoptosis and autophagy in cancer cells in vitro (IC50 = 3.4 - 12 μM)
- In vivo , ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat
- No
- 7282), Docetaxel (Cat
- No
- 4056) and Erlotinib (Cat
- No
- 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat
- No
- 4499)
- ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo , and clears senescent cells and rejuvenates aging stem cells
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Target: Bcl-2 Family Inhibitors
Purity: 0.98
CAS: 923564-51-6
Molecular Formula: C47H55ClF3N5O6S3
Chemical Name or Material:
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Target:
Bcl-2 Family Inhibitors
Purity:
0.98
CAS:
923564-51-6
Molecular Formula:
C47H55ClF3N5O6S3
Chemical Name or Material: 2-Chloro-N-(2-furanylmethyl)-7 H-purin-6-amine
Target: DNA, RNA and Protein Synthesis Compounds
Purity: 0.98
CAS: 101862-47-9
Molecular Formula: C10H8ClN5O
Chemical Name or Material:
2-Chloro-N-(2-furanylmethyl)-7 H-purin-6-amine
Target:
DNA, RNA and Protein Synthesis Compounds
Purity:
0.98
CAS:
101862-47-9
Molecular Formula:
C10H8ClN5O
Chemical Name or Material: 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Target: LMTK3
Purity: 0.98
CAS: __
Molecular Formula: C18H11F3N4O
Chemical Name or Material:
6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Target:
LMTK3
Purity:
0.98
CAS:
__
Molecular Formula:
C18H11F3N4O
Chemical Name or Material: N-[(1-Methyl-1 H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine
Target: Hydrolase Inhibitors
Purity: 0.98
CAS: 2757254-99-0
Molecular Formula: C15H22N6
Chemical Name or Material:
N-[(1-Methyl-1 H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine
Target:
Hydrolase Inhibitors
Purity:
0.98
CAS:
2757254-99-0
Molecular Formula:
C15H22N6