76-801-0
Tocris Bioscience™ ABT 263
Manufacturer: Fischer Scientific
CAS Number: 923564-51-6
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 76-801-0-Each-of-1 | In Stock | ₹ 16,580.70 |
76-801-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,580.70
GST (18%): ₹ 2,984.526
Total Price: ₹ 19,565.226
Chemical Name or Material
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Quantity
10 mg
Molecular Formula
C47H55ClF3N5O6S3
CAS
923564-51-6
Target
Bcl-2 Family Inhibitors
Purity
0.98
Other Options
Related Products
Description
- ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (Ki values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively)
- ABT 263 induces G1/G0 phase arrest, apoptosis and autophagy in cancer cells in vitro (IC50 = 3.4 - 12 μM)
- In vivo , ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat
- No
- 7282), Docetaxel (Cat
- No
- 4056) and Erlotinib (Cat
- No
- 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat
- No
- 4499)
- ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo , and clears senescent cells and rejuvenates aging stem cells
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Quantity: 10 mg
Molecular Formula: C47H55ClF3N5O6S3
CAS: 923564-51-6
Target: Bcl-2 Family Inhibitors
Purity: 0.98
Chemical Name or Material:
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Quantity:
10 mg
Molecular Formula:
C47H55ClF3N5O6S3
CAS:
923564-51-6
Target:
Bcl-2 Family Inhibitors
Purity:
0.98
Chemical Name or Material: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Quantity: 50 mg
Molecular Formula: C47H55ClF3N5O6S3
CAS: 923564-51-6
Target: Bcl-2 Family Inhibitors
Purity: 0.98
Chemical Name or Material:
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1 R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Quantity:
50 mg
Molecular Formula:
C47H55ClF3N5O6S3
CAS:
923564-51-6
Target:
Bcl-2 Family Inhibitors
Purity:
0.98
Chemical Name or Material: 4-Chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-α-(2-propyn-1-yloxy)benzeneacetamide
Quantity: 10 mg
Molecular Formula: C23H22ClNO4
CAS: 374726-62-2
Target: Protein Dimerizers
Purity: 0.98
Chemical Name or Material:
4-Chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-α-(2-propyn-1-yloxy)benzeneacetamide
Quantity:
10 mg
Molecular Formula:
C23H22ClNO4
CAS:
374726-62-2
Target:
Protein Dimerizers
Purity:
0.98
Chemical Name or Material: 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide
Quantity: 5 mg
Molecular Formula: C48H52F4N6O9
CAS: 2417097-18-6
Target: Active Degraders
Purity: 98%
Chemical Name or Material:
12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide
Quantity:
5 mg
Molecular Formula:
C48H52F4N6O9
CAS:
2417097-18-6
Target:
Active Degraders
Purity:
98%