200007276
Tocris Bioscience™ LY 2109761
Selective TGF-β kinase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 700874-71-1
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Chemical Name or Material
4-[5,6-Dihydro-2-(2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline
Target
TGF-beta Receptor Inhibitors
Purity
0.98
CAS
700874-71-1
Molecular Formula
C26H27N5O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ LY 2109761 | Fischer Scientific | ₹ 13,234.30 | |
| | Tocris Bioscience™ LY 2109761 | Fischer Scientific | ₹ 55,714.00 |
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Description
- LY 2109761 is a selective dual TGF-β receptor type I and II (TβRI/II) inhibitor (Ki values are 38 and 300 nM in a cell-free assay, respectively); it inhibits the kinase activity of both TGF-βRI and TGF-βRII
- In vitro , it significantly inhibits the growth, motility, and invasiveness of L3.6pl/GLT pancreatic cancer cells and completely suppresses TGF-β-induced Smad2 phosphorylation
- In vivo , LY 2109761, in combination with Gemcitabine, significantly reduces tumor volume and spontaneous abdominal metastases in a murine model of metastatic pancreatic cancer
- LY 2109761 is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-[5,6-Dihydro-2-(2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline
Target: TGF-beta Receptor Inhibitors
Purity: 0.98
CAS: 700874-71-1
Molecular Formula: C26H27N5O2
Chemical Name or Material:
4-[5,6-Dihydro-2-(2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline
Target:
TGF-beta Receptor Inhibitors
Purity:
0.98
CAS:
700874-71-1
Molecular Formula:
C26H27N5O2
Chemical Name or Material: 2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
Target: p62/SQSTM1
Purity: 0.98
CAS: 2421146-32-7
Molecular Formula: C23H25NO3.HCl
Chemical Name or Material:
2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
Target:
p62/SQSTM1
Purity:
0.98
CAS:
2421146-32-7
Molecular Formula:
C23H25NO3.HCl
Chemical Name or Material: 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Target: Synthase/Synthetase Inhibitors
Purity: 0.98
CAS: 2262452-06-0
Molecular Formula: C19H12Cl2N4O3
Chemical Name or Material:
3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Target:
Synthase/Synthetase Inhibitors
Purity:
0.98
CAS:
2262452-06-0
Molecular Formula:
C19H12Cl2N4O3
Chemical Name or Material: 2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2 H-pyran-2-yl)methoxy]phenyl]-2 H-indazole-3-carboxamide
Target: IP3R1
Purity: 0.98
CAS: 1214569-31-9
Molecular Formula: C22H29N3O3
Chemical Name or Material:
2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2 H-pyran-2-yl)methoxy]phenyl]-2 H-indazole-3-carboxamide
Target:
IP3R1
Purity:
0.98
CAS:
1214569-31-9
Molecular Formula:
C22H29N3O3