200086924
Tocris Bioscience™ CAF 382
Potent and selective CDKL5 inhibitor
Manufacturer: Fischer Scientific
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Chemical Name or Material
N-[5-[(5-Propan-2-yl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide trifluoroacetate
Target
CDKL5
Molecular Formula
C16H22N4O2S2.CF3CO2H
Purity
0.98
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Description
- CAF 382 is potent and selective CDKL5 (cyclin-dependent kinase-like 5) inhibitor (IC50 = 10 nM)
- Exhibits nearly 100-fold selectivity for CDKL5 over CDKL2, low inhibition for CDKL3 and CDKL4 (IC50 = 2.1-2.7 ?M), and no inhibition for CDKL1
- CAF 382 lacks GSK3β activity
- It causes a significant reduction in pSer222 EB2 at 5 nM without a change in total EB2 levels in rat primary cortical neuron cultures
- CAF 382 is an analog of SNS 032 (Cat
- No
- 4075).
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: N-[5-[(5-Propan-2-yl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide trifluoroacetate
Target: CDKL5
Molecular Formula: C16H22N4O2S2.CF3CO2H
Purity: 0.98
Chemical Name or Material:
N-[5-[(5-Propan-2-yl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide trifluoroacetate
Target:
CDKL5
Molecular Formula:
C16H22N4O2S2.CF3CO2H
Purity:
0.98
Chemical Name or Material: 8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Target: Other Kinase Inhibitors
Molecular Formula: C26H29ClN6O3.3HCl
Purity: 0.98
Chemical Name or Material:
8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Target:
Other Kinase Inhibitors
Molecular Formula:
C26H29ClN6O3.3HCl
Purity:
0.98
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