56-061-0
Tocris Bioscience™ LOC14
Manufacturer: Tocris Bioscience™
CAS Number: 877963-94-5
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Chemical Name or Material
2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one
Quantity
10 mg
Molecular Formula
C16H19N3O2S
Purity
>98%
CAS
877963-94-5
Target
Other Reductase Inhibitors
Formula Weight
317.41
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-100432 25mg Medchemexpress, LOC14 CAS:877963-94-5 Purity:>98% | Medchemexpress LLC | ₹ 21,586.95 | |
 | Medchemexpress LLC HY-100432 5mg Medchemexpress, LOC14 CAS:877963-94-5 Purity:>98% | Medchemexpress LLC | ₹ 5,139.75 | |
 | 877963-94-5 | 2-[(4-cyclopropanecarbonylpiperazin-1-yl)methyl]-2,3-dihydro-1,2-benzothiazol-3-one | A2B Chem | ₹ 2,314.00 - ₹ 23,585.00 |
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Description
- LOC14 is a high affinity allosteric inhibitor of protein disulfide isomerase A3 (PDIA3) modulator (Kd = 62 nM, IC50 = 5 μM)
- In an animal model of Huntington's disease LOC14 extends survival, improves motor function, reduces ER stress from mHTT and preserves dopamine and DARPP32 levels
- LOC14 is neuroprotective and rescues medium spiny neurons from neurodegeneration
- LOC14 also decreases influenza A protein production in cells (IC50 = 4.97 μM).
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
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Chemical Name or Material: 2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one
Quantity: 10 mg
Molecular Formula: C16H19N3O2S
Purity: >98%
CAS: 877963-94-5
Target: Other Reductase Inhibitors
Formula Weight: 317.41
Chemical Name or Material:
2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one
Quantity:
10 mg
Molecular Formula:
C16H19N3O2S
Purity:
>98%
CAS:
877963-94-5
Target:
Other Reductase Inhibitors
Formula Weight:
317.41
Chemical Name or Material: __
Quantity: 100 μg
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