60-705-00U
Tocris Bioscience™ Pladienolide B
Manufacturer: Tocris Bioscience™
CAS Number: 445493-23-2
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 60-705-00U-Each-of-1 | In Stock | ₹ 48,213.06 |
60-705-00U - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,213.06
GST (18%): ₹ 8,678.351
Total Price: ₹ 56,891.411
Chemical Name or Material
Pladienolide B
Synonym
(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Solubility
Soluble to 1mg/mL in DMSO
Formula Weight
536.7
Color
Colorless
Purity
>95%
CAS
445493-23-2
Quantity
500 μg
Molecular Formula
C30H48O8
Physical Form
Film
Product Type
Bioactive Small Molecule
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Santa Cruz Biotechnology Pladienolide B, 445493-23-2, MFCD22572773, 5 mg | Santa Cruz Biotechnology | ₹ 29,347.08 | |
 | 445493-23-2 | 11107B | A2B Chem | ₹ 1,55,291.40 - ₹ 2,55,995.52 |
Related Products
Description
- Pladienolide B is a mRNA splicing inhibitor that decreases splicing capacity up to 75% in vitro
- Pladienolide B directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA
- Pladienolide B arrests the cell cycle in G1 and G2/M phases and displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM)
- Cell permeable and active in vivo .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: Pladienolide B
Synonym: (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Solubility: Soluble to 1mg/mL in DMSO
Formula Weight: 536.7
Color: Colorless
Purity: >95%
CAS: 445493-23-2
Quantity: 500 μg
Molecular Formula: C30H48O8
Physical Form: Film
Product Type: Bioactive Small Molecule
Chemical Name or Material:
Pladienolide B
Synonym:
(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Solubility:
Soluble to 1mg/mL in DMSO
Formula Weight:
536.7
Color:
Colorless
Purity:
>95%
CAS:
445493-23-2
Quantity:
500 μg
Molecular Formula:
C30H48O8
Physical Form:
Film
Product Type:
Bioactive Small Molecule
Chemical Name or Material: CZC 25146
Synonym: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Solubility: Soluble to 100mM in DMSO
Formula Weight: 488.54
Color: Pale-purple
Purity: >98%
CAS: 1191911-26-8
Quantity: 10 mg
Molecular Formula: C22H25FN6O4S
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
CZC 25146
Synonym:
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Solubility:
Soluble to 100mM in DMSO
Formula Weight:
488.54
Color:
Pale-purple
Purity:
>98%
CAS:
1191911-26-8
Quantity:
10 mg
Molecular Formula:
C22H25FN6O4S
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: CZC 25146
Synonym: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Solubility: Soluble to 100mM in DMSO
Formula Weight: 488.54
Color: Pale-purple
Purity: >98%
CAS: 1191911-26-8
Quantity: 50 mg
Molecular Formula: C22H25FN6O4S
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
CZC 25146
Synonym:
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Solubility:
Soluble to 100mM in DMSO
Formula Weight:
488.54
Color:
Pale-purple
Purity:
>98%
CAS:
1191911-26-8
Quantity:
50 mg
Molecular Formula:
C22H25FN6O4S
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N′-[4-(trifluoromethoxy)phenyl]urea
Synonym: __
Solubility: __
Formula Weight: Observed MW: 445.43
Color: __
Purity: __
CAS: 870544-59-5
Quantity: 10 mg
Molecular Formula: C23H22F3N3O3
Physical Form: __
Product Type: __
Chemical Name or Material:
N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N′-[4-(trifluoromethoxy)phenyl]urea
Synonym:
__
Solubility:
__
Formula Weight:
Observed MW: 445.43
Color:
__
Purity:
__
CAS:
870544-59-5
Quantity:
10 mg
Molecular Formula:
C23H22F3N3O3
Physical Form:
__
Product Type:
__