7082174
Tocris Bioscience™ JTE 607 Dihydrochloride
Cytokine release inhibitor; anti-inflammatory
Manufacturer: Fischer Scientific
CAS Number: 188791-09-5
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Chemical Name or Material
JTE 607 dihydrochloride
Synonym
N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Molecular Formula
C25H31Cl2N3O5·2HCl
Physical Form
Solid
Purity
>98%
CAS
188791-09-5
Solubility
Soluble to 100mM in water and to 100mM in DMSO
Formula Weight
597.36
Product Type
Bioactive Small Molecule
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ JTE 607 Dihydrochloride | Fischer Scientific | ₹ 1,39,548.36 | |
| | Tocris Bioscience™ JTE 607 Dihydrochloride | Fischer Scientific | ₹ 33,411.18 | |
 | Medchemexpress LLC HY-110133 10mg , JTE-607 CAS:188791-09-5 Purity:>98% | Medchemexpress LLC | ₹ 17,787.92 | |
 | eMolecules Medchem Express / JTE-607 / 5mg / 686240174 / HY-110133 / / 188791-09-5 / MFCD07363998 / 597.360 / C25H33Cl4N3O5 | eMolecules | ₹ 13,853.88 | |
 | 188791-09-5 | JTE607Dihydrochloride | A2B Chem | ₹ 6,930.36 - ₹ 71,442.60 |
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Description
- Cytokine release inhibitor
- Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs
- Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model
- Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
SAFETY INFORMATION
- Recommended Storage : Desiccate at Room Temperature
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Chemical Name or Material: JTE 607 dihydrochloride
Synonym: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Molecular Formula: C25H31Cl2N3O5·2HCl
Physical Form: Solid
Purity: >98%
CAS: 188791-09-5
Solubility: Soluble to 100mM in water and to 100mM in DMSO
Formula Weight: 597.36
Product Type: Bioactive Small Molecule
Chemical Name or Material:
JTE 607 dihydrochloride
Synonym:
N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Molecular Formula:
C25H31Cl2N3O5·2HCl
Physical Form:
Solid
Purity:
>98%
CAS:
188791-09-5
Solubility:
Soluble to 100mM in water and to 100mM in DMSO
Formula Weight:
597.36
Product Type:
Bioactive Small Molecule
Chemical Name or Material: NK 252
Synonym: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Molecular Formula: C13H11N5O3
Physical Form: Powder
Purity: >98%
CAS: 1414963-82-8
Solubility: Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Formula Weight: 285.26
Product Type: Bioactive Small Molecule
Chemical Name or Material:
NK 252
Synonym:
N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Molecular Formula:
C13H11N5O3
Physical Form:
Powder
Purity:
>98%
CAS:
1414963-82-8
Solubility:
Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Formula Weight:
285.26
Product Type:
Bioactive Small Molecule
Chemical Name or Material: TC-I 2014
Synonym: 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Molecular Formula: C23H19F6N3O
Physical Form: Powder
Purity: >98%
CAS: 1221349-53-6
Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
Formula Weight: 467.41
Product Type: Bioactive Small Molecule
Chemical Name or Material:
TC-I 2014
Synonym:
3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Molecular Formula:
C23H19F6N3O
Physical Form:
Powder
Purity:
>98%
CAS:
1221349-53-6
Solubility:
Soluble to 100mM in DMSO and to 100mM in ethanol
Formula Weight:
467.41
Product Type:
Bioactive Small Molecule
Chemical Name or Material: Ras GTPase Inhibitors
Synonym: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Molecular Formula: C25H20N4O3
Physical Form: Solid
Purity: >98%
CAS: 361185-42-4
Solubility: Soluble to 100mM in DMSO
Formula Weight: 424.45
Product Type: Bioactive Small Molecule
Chemical Name or Material:
Ras GTPase Inhibitors
Synonym:
6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Molecular Formula:
C25H20N4O3
Physical Form:
Solid
Purity:
>98%
CAS:
361185-42-4
Solubility:
Soluble to 100mM in DMSO
Formula Weight:
424.45
Product Type:
Bioactive Small Molecule