7082182
Tocris Bioscience™ PFK 15
Selective PFKFB3 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 4382-63-2
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Chemical Name or Material
PFK 15
Synonym
1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Molecular Formula
C17H12N2O
Physical Form
Solid
Purity
>99%
CAS
4382-63-2
Solubility
Soluble to 100mM in DMSO
Formula Weight
260.29
Product Type
Bioactive Small Molecule
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ PFK 15 | Fischer Scientific | ₹ 18,267.06 | |
| | Tocris Bioscience™ PFK 15 | Fischer Scientific | ₹ 76,405.08 | |
 | Sigma Aldrich Fine Chemicals Biosciences PFK15 >=98% (HPLC) | 4382-63-2 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 50,206.61 |
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Description
- Description Originally reported to be a selective PFKFB3 inhibitor (IC50 = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay
- Selective for PFKFB3 over a panel of 96 kinases
- Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells
- Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: PFK 15
Synonym: 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Molecular Formula: C17H12N2O
Physical Form: Solid
Purity: >99%
CAS: 4382-63-2
Solubility: Soluble to 100mM in DMSO
Formula Weight: 260.29
Product Type: Bioactive Small Molecule
Chemical Name or Material:
PFK 15
Synonym:
1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Molecular Formula:
C17H12N2O
Physical Form:
Solid
Purity:
>99%
CAS:
4382-63-2
Solubility:
Soluble to 100mM in DMSO
Formula Weight:
260.29
Product Type:
Bioactive Small Molecule
Chemical Name or Material: VU 0469650 hydrochloride
Synonym: 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
Molecular Formula: C22H28N4O·HCl
Physical Form: Solid
Purity: >98%
CAS: 1443748-47-7
Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
Formula Weight: 400.94
Product Type: Bioactive Small Molecule
Chemical Name or Material:
VU 0469650 hydrochloride
Synonym:
3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
Molecular Formula:
C22H28N4O·HCl
Physical Form:
Solid
Purity:
>98%
CAS:
1443748-47-7
Solubility:
Soluble to 100mM in DMSO and to 50mM in ethanol
Formula Weight:
400.94
Product Type:
Bioactive Small Molecule
Chemical Name or Material: AM 6545
Synonym: 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
Molecular Formula: C26H23Cl2N5O3S
Physical Form: Solid
Purity: >98%
CAS: 1245626-05-4
Solubility: Soluble to 20mM in DMSO
Formula Weight: 556.46
Product Type: Bioactive Small Molecule
Chemical Name or Material:
AM 6545
Synonym:
5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
Molecular Formula:
C26H23Cl2N5O3S
Physical Form:
Solid
Purity:
>98%
CAS:
1245626-05-4
Solubility:
Soluble to 20mM in DMSO
Formula Weight:
556.46
Product Type:
Bioactive Small Molecule
Chemical Name or Material: QAQ dichloride
Synonym: 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
Molecular Formula: C28H44Cl2N6O2
Physical Form: Solid
Purity: >98%
CAS: __
Solubility: Soluble to 50mM in water
Formula Weight: 567.59
Product Type: Bioactive Small Molecule
Chemical Name or Material:
QAQ dichloride
Synonym:
2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
Molecular Formula:
C28H44Cl2N6O2
Physical Form:
Solid
Purity:
>98%
CAS:
__
Solubility:
Soluble to 50mM in water
Formula Weight:
567.59
Product Type:
Bioactive Small Molecule